An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the PANCREAS and CONGENITAL HYPERINSULINISM. It is due to focal hyperplasia of pancreatic ISLET CELLS budding off from the ductal structures and forming new islets of Langerhans. Mutations in the islet cells involve the potassium channel gene KCNJ11 or the ATP-binding cassette transporter gene ABCC8, both on CHROMOSOME 11.

DUI

D046768 MeSH Browser

CUI

M0015793

Previous indexing

Hyperinsulinism (1971-2004); Hyperplasia (1968-2004); Islets of Langerhans (1968-2004)

History note

2005; use PANCREATIC DISEASES 1983-2004

Public note

2005; see PANCREATIC DISEASES 1983-2004