antigeny CD274 [B7-H1 Antigen]

tematický
247
Termíny

Antigens, CD274
B7-H1 Immune Costimulatory Protein
B7H1 Immune Costimulatory Protein
CD274 Antigen
PD-L1 Costimulatory Protein
PD-L1 Protein
Programmed Cell Death 1 Ligand 1
Programmed Cell Death 1 Ligand 1 Protein
Programmed Death Ligand 1

Perzistentní odkaz   https://www.medvik.cz/link/D060890
Definice

Inhibiční antigen B7, který obsahuje imunoglobulinové domény V a C2. Je specifický pro T-buněčný ligand PD-1 a vysílá negativní signály, které kontrolují a inhibují odpovědi T-buněk. Na nádorových buňkách se vyskytuje ve vyšších hladinách, než je obvyklé, což naznačuje jeho potenciální roli v úniku nádorů před imunitním systémem.

An inhibitory B7 antigen that contains V-type and C2 type immunoglobulin domains. It has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN and provides negative signals that control and inhibit T-cell responses. It is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.

DUI
D060890 MeSH Prohlížeč
CUI
M0555734
Předchozí užití
Antigens, CD (2007-2011); Antigens, CD80 (2001-2006); Blood Proteins (2001-2005)
Historická pozn.
2018 (2007)
Veřejná pozn.
2018; see ANTIGENS, CD274 2012-2017

D Chemikálie a léčiva
D12.776 proteiny 2 575
D12.776.465.500 antigeny CD86 14
D12.776.465.625 antigeny CD274 247
D12.776.465.750 antigeny CD40 17
D12.776.465.782 antigen CTLA-4 191
D12.776.465.813 ligand OX40 1
D12.776.465.829 antigeny CD273 15
D12.776.465.844 antigeny CD279 291
D12.776.465.875 receptory OX40 2
D12.776.467.150 antigeny B7 3
D12.776.467.150.100 antigeny CD80 25
D12.776.467.150.200 antigeny CD86 14
D12.776.467.150.300 antigeny CD274 247
D12.776.467.150.500 antigeny CD275
D12.776.467.150.800 antigeny CD273 15
D12.776.467.150.900 kostimulační protein B7H4
D12.776.543 membránové proteiny 849
D12.776.543.095 antigeny B7 3
D12.776.543.095.100 antigeny CD80 25
D12.776.543.095.200 antigeny CD86 14
D12.776.543.095.300 antigeny CD274 247
D12.776.543.095.500 antigeny CD275
D12.776.543.095.800 antigeny CD273 15
D12.776.543.095.900 kostimulační protein B7H4
D23.050 antigeny 1 131
D23.050.301 antigeny povrchové 170
D23.050.301.285 antigeny B7 3
D23.050.301.285.100 antigeny CD80 25
D23.050.301.285.200 antigeny CD86 14
D23.050.301.285.400 antigeny CD274 247
D23.050.301.285.500 antigeny CD275
D23.050.301.285.800 antigeny CD273 15
D23.050.301.285.900 kostimulační protein B7H4
D23.529.168 antigeny B7 3
D23.529.168.100 antigeny CD80 25
D23.529.168.200 antigeny CD86 14
D23.529.168.300 antigeny CD274 247
D23.529.168.500 antigeny CD275
D23.529.168.800 antigeny CD273 15