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Autor
Abnet, Christian C 1 Albanes, Demetrius 1 Amundadottir, Laufey T 1 Andreotti, Gabriella 1 Arslan, Alan A 1 Austin, Melissa A 1 Barfield, Richard 1 Basso, Daniela 1 Beane-Freeman, Laura 1 Berndt, Sonja I 1 Boutron-Ruault, Marie-Christine 1 Bracci, Paige M 1 Brotzman, Michelle 1 Bueno-de-Mesquita, H Bas 1 Bugert, Peter 1 Burdette, Laurie 1 Buring, Julie 1 Büchler, Markus W 1 Campa, Daniele 1 Canzian, Federico 1
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Pracoviště
1st Propaideutic Surgical Department ... 1 ARC NET Centre for Applied Research o... 1 Alliance Statistics and Data Center D... 1 Alliance Statistics and Data Center D... 1 Cancer Epidemiology Program Universit... 1 Cancer Epidemiology Unit University o... 1 Cancer Prevention University of South... 1 Department of Biology University of P... 1 Department of Biostatistics Harvard S... 1 Department of Chronic Disease Epidemi... 1 Department of Chronic Disease Prevent... 1 Department of Digestive Tract Disease... 1 Department of Epidemiology Fred Hutch... 1 Department of Epidemiology Harvard Sc... 1 Department of Epidemiology Johns Hopk... 1 Department of Epidemiology University... 1 Department of Epidemiology and Biosta... 1 Department of Epidemiology and Biosta... 1 Department of Epidemiology and Biosta... 1 Department of Gastroenterology Lithua... 1
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Autor
Abnet, Christian C 1 Albanes, Demetrius 1 Amundadottir, Laufey T 1 Andreotti, Gabriella 1 Arslan, Alan A 1 Austin, Melissa A 1 Barfield, Richard 1 Basso, Daniela 1 Beane-Freeman, Laura 1 Berndt, Sonja I 1 Boutron-Ruault, Marie-Christine 1 Bracci, Paige M 1 Brotzman, Michelle 1 Bueno-de-Mesquita, H Bas 1 Bugert, Peter 1 Burdette, Laurie 1 Buring, Julie 1 Büchler, Markus W 1 Campa, Daniele 1 Canzian, Federico 1
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Pracoviště
1st Propaideutic Surgical Department ... 1 ARC NET Centre for Applied Research o... 1 Alliance Statistics and Data Center D... 1 Alliance Statistics and Data Center D... 1 Cancer Epidemiology Program Universit... 1 Cancer Epidemiology Unit University o... 1 Cancer Prevention University of South... 1 Department of Biology University of P... 1 Department of Biostatistics Harvard S... 1 Department of Chronic Disease Epidemi... 1 Department of Chronic Disease Prevent... 1 Department of Digestive Tract Disease... 1 Department of Epidemiology Fred Hutch... 1 Department of Epidemiology Harvard Sc... 1 Department of Epidemiology Johns Hopk... 1 Department of Epidemiology University... 1 Department of Epidemiology and Biosta... 1 Department of Epidemiology and Biosta... 1 Department of Epidemiology and Biosta... 1 Department of Gastroenterology Lithua... 1
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- Wolpin, Brian M
- Rizzato, Cosmeri
- Kraft, Peter
- Kooperberg, Charles
- Petersen, Gloria M
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Wang, Zhaoming
Autor Wang, Zhaoming ] Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [2] Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
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Arslan, Alan A
Autor Arslan, Alan A ] Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA. [2] Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA. [3] New York University Cancer Institute, New York, New York, USA
- Beane-Freeman, Laura
- Bracci, Paige M
- Buring, Julie
Medline Complete (EBSCOhost) od 1998-06-01 do 2015-11-30
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 2000-01-01 do Před 1 rokem
PubMed
25086665
DOI
10.1038/ng.3052
Knihovny.cz E-zdroje
We performed a multistage genome-wide association study including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT, per-allele odds ratio (OR) = 0.79, 95% confidence interval (CI) 0.74-0.84, P = 3.0 × 10(-12)), rs7190458 at 16q23.1 (BCAR1/CTRB1/CTRB2, OR = 1.46, 95% CI 1.30-1.65, P = 1.1 × 10(-10)), rs9581943 at 13q12.2 (PDX1, OR = 1.15, 95% CI 1.10-1.20, P = 2.4 × 10(-9)) and rs16986825 at 22q12.1 (ZNRF3, OR = 1.18, 95% CI 1.12-1.25, P = 1.2 × 10(-8)). We identified an independent signal in exon 2 of TERT at the established region 5p15.33 (rs2736098, OR = 0.80, 95% CI 0.76-0.85, P = 9.8 × 10(-14)). We also identified a locus at 8q24.21 (rs1561927, P = 1.3 × 10(-7)) that approached genome-wide significance located 455 kb telomeric of PVT1. Our study identified multiple new susceptibility alleles for pancreatic cancer that are worthy of follow-up studies.
- MeSH
- běloši genetika MeSH
- celogenomová asociační studie metody MeSH
- genetická predispozice k nemoci MeSH
- genetické lokusy * MeSH
- genotyp MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory slinivky břišní genetika MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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