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Autor
Albanes, Demetrius 1 Alwers, Elizabeth 1 Amitay, Efrat 1 Baron, John A 1 Bermejo, Justo Lorenzo 1 Berndt, Sonja I 1 Bishop, D Timothy 1 Brenner, Hermann 1 Buchanan, Daniel D 1 Butterworth, Adam 1 Campbell, Peter T 1 Casey, Graham 1 Castellví-Bel, Sergi 1 Chan, Andrew T 1 Chang-Claude, Jenny 1 Drew, David A 1 Figueiredo, Jane C 1 Gallinger, Steven 1 Giles, Graham G 1 Gruber, Stephen B 1
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Pracoviště
British Heart Foundation Cardiovascul... 1 British Heart Foundation Centre of Re... 1 Broad Institute of Harvard and MIT Ca... 1 CIBER Epidemiología y Salud Pública 2... 1 Cancer Epidemiology Division Cancer C... 1 Cancer Epidemiology Program Universit... 1 Center for Gastrointestinal Biology a... 1 Center for Public Health Genomics Dep... 1 Centre for Epidemiology and Biostatis... 1 Channing Division of Network Medicine... 1 Clalit National Cancer Control Center... 1 Clinical and Translational Epidemiolo... 1 Colorectal Oncogenomics Group Departm... 1 Department of Clinical Genetics Karol... 1 Department of Clinical Sciences Facul... 1 Department of Community Medicine and ... 1 Department of Epidemiology Harvard T ... 1 Department of Epidemiology Institute ... 1 Department of Epidemiology Johns Hopk... 1 Department of Epidemiology University... 1
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Autor
Albanes, Demetrius 1 Alwers, Elizabeth 1 Amitay, Efrat 1 Baron, John A 1 Bermejo, Justo Lorenzo 1 Berndt, Sonja I 1 Bishop, D Timothy 1 Brenner, Hermann 1 Buchanan, Daniel D 1 Butterworth, Adam 1 Campbell, Peter T 1 Casey, Graham 1 Castellví-Bel, Sergi 1 Chan, Andrew T 1 Chang-Claude, Jenny 1 Drew, David A 1 Figueiredo, Jane C 1 Gallinger, Steven 1 Giles, Graham G 1 Gruber, Stephen B 1
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Pracoviště
British Heart Foundation Cardiovascul... 1 British Heart Foundation Centre of Re... 1 Broad Institute of Harvard and MIT Ca... 1 CIBER Epidemiología y Salud Pública 2... 1 Cancer Epidemiology Division Cancer C... 1 Cancer Epidemiology Program Universit... 1 Center for Gastrointestinal Biology a... 1 Center for Public Health Genomics Dep... 1 Centre for Epidemiology and Biostatis... 1 Channing Division of Network Medicine... 1 Clalit National Cancer Control Center... 1 Clinical and Translational Epidemiolo... 1 Colorectal Oncogenomics Group Departm... 1 Department of Clinical Genetics Karol... 1 Department of Clinical Sciences Facul... 1 Department of Community Medicine and ... 1 Department of Epidemiology Harvard T ... 1 Department of Epidemiology Institute ... 1 Department of Epidemiology Johns Hopk... 1 Department of Epidemiology University... 1
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- Nounu, Aayah
- Richmond, Rebecca C
- Stewart, Isobel D
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Surendran, Praveen
Autor Surendran, Praveen British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, University of Cambridge, Cambridge CB2 0QQ, UK Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge CB10 1SA, UK Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
- Wareham, Nicholas J
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Butterworth, Adam
Autor Butterworth, Adam British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, University of Cambridge, Cambridge CB2 0QQ, UK Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge CB10 1SA, UK National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge CB2 1TN, UK National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge University Hospitals, Cambridge CB2 0QQ, UK
- Weinstein, Stephanie J
- Albanes, Demetrius
- Baron, John A
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Hopper, John L
Autor Hopper, John L Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3053, Australia Department of Epidemiology, Institute of Health and Environment, School of Public Health, Seoul National University, Seoul 08826, Korea
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PubMed
34836419
DOI
10.3390/nu13114164
Knihovny.cz E-zdroje
Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a Mendelian randomization (MR) approach, we aimed to address whether levels of SA affected CRC risk, stratifying by aspirin use. A two-sample MR analysis was performed using GWAS summary statistics of SA (INTERVAL and EPIC-Norfolk, N = 14,149) and CRC (CCFR, CORECT, GECCO and UK Biobank, 55,168 cases and 65,160 controls). The DACHS study (4410 cases and 3441 controls) was used for replication and stratification of aspirin-use. SNPs proxying SA were selected via three methods: (1) functional SNPs that influence the activity of aspirin-metabolising enzymes; (2) pathway SNPs present in enzymes' coding regions; and (3) genome-wide significant SNPs. We found no association between functional SNPs and SA levels. The pathway and genome-wide SNPs showed no association between SA and CRC risk (OR: 1.03, 95% CI: 0.84-1.27 and OR: 1.08, 95% CI: 0.86-1.34, respectively). Results remained unchanged upon aspirin use stratification. We found little evidence to suggest that an SD increase in genetically predicted SA protects against CRC risk in the general population and upon stratification by aspirin use.
- MeSH
- Aspirin terapeutické užití MeSH
- celogenomová asociační studie MeSH
- dieta MeSH
- genotypizační techniky MeSH
- jednonukleotidový polymorfismus MeSH
- kolorektální nádory krev epidemiologie genetika prevence a kontrola MeSH
- kyselina salicylová aplikace a dávkování krev MeSH
- lidé MeSH
- mendelovská randomizace MeSH
- rizikové faktory MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
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