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Autor
Abdelkader, Nejma 1 Bossut, Noelie 1 Castoldi, Francesca 1 Chen, Guo 1 Codogno, Patrice 1 Dupont, Nicolas 1 Durand, Sylvere 1 Enot, David P 1 Kroemer, Guido 1 Kroemer, Romano 1 Lachkar, Sylvie 1 Loos, Friedemann 1 Madeo, Frank 1 Maiuri, Maria Chiara 1 Malik, Shoaib A 1 Mariño, Guillermo 1 Markaki, Maria 1 Pietrocola, Federico 1 Sadoshima, Junichi 1 Tavernarakis, Nektarios 1
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Pracoviště
BioTechMed Graz Humboldtstraße 50 801... 1 CNRS UMR8253 Paris France 1 Departamento de Biología Fundamental ... 1 Department of Basic Sciences Faculty ... 1 Department of Biochemistry Sargodha M... 1 Department of Cell Biology and Molecu... 1 Equipe 11 labellisée par la Ligue Nat... 1 Gustave Roussy Cancer Campus Villejui... 1 INSERM U1138 Paris France 1 INSERM U1151 Paris France 1 Institut Necker Enfants Malades Paris... 1 Institute of Molecular Biology and Bi... 1 Institute of Molecular Biosciences NA... 1 Instituto de Investigación Sanitaria ... 1 Karolinska Institute Department of Wo... 1 Metabolomics and Cell Biology Platfor... 1 Pôle de Biologie Hôpital Européen Geo... 1 Scientific Computing LGCR Sanofi R an... 1 Sotio a c Prague Czech Republic 1 Structure Design and Informatics LGCR... 1
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Autor
Abdelkader, Nejma 1 Bossut, Noelie 1 Castoldi, Francesca 1 Chen, Guo 1 Codogno, Patrice 1 Dupont, Nicolas 1 Durand, Sylvere 1 Enot, David P 1 Kroemer, Guido 1 Kroemer, Romano 1 Lachkar, Sylvie 1 Loos, Friedemann 1 Madeo, Frank 1 Maiuri, Maria Chiara 1 Malik, Shoaib A 1 Mariño, Guillermo 1 Markaki, Maria 1 Pietrocola, Federico 1 Sadoshima, Junichi 1 Tavernarakis, Nektarios 1
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Pracoviště
BioTechMed Graz Humboldtstraße 50 801... 1 CNRS UMR8253 Paris France 1 Departamento de Biología Fundamental ... 1 Department of Basic Sciences Faculty ... 1 Department of Biochemistry Sargodha M... 1 Department of Cell Biology and Molecu... 1 Equipe 11 labellisée par la Ligue Nat... 1 Gustave Roussy Cancer Campus Villejui... 1 INSERM U1138 Paris France 1 INSERM U1151 Paris France 1 Institut Necker Enfants Malades Paris... 1 Institute of Molecular Biology and Bi... 1 Institute of Molecular Biosciences NA... 1 Instituto de Investigación Sanitaria ... 1 Karolinska Institute Department of Wo... 1 Metabolomics and Cell Biology Platfor... 1 Pôle de Biologie Hôpital Européen Geo... 1 Scientific Computing LGCR Sanofi R an... 1 Sotio a c Prague Czech Republic 1 Structure Design and Informatics LGCR... 1
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Pietrocola, Federico
Autor Pietrocola, Federico Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France
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Castoldi, Francesca
Autor Castoldi, Francesca Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France Université Paris-Sud/Paris XI, Faculté de Médecine, Kremlin-Bicêtre, France, Paris, France Sotio a.c., Prague, Czech Republic
- Markaki, Maria
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Lachkar, Sylvie
Autor Lachkar, Sylvie Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France
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Chen, Guo
Autor Chen, Guo Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France
- Enot, David P
- Durand, Sylvere
- Bossut, Noelie
- Tong, Mingming
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Malik, Shoaib A
Autor Malik, Shoaib A Gustave Roussy Cancer Campus, Villejuif, France INSERM, U1138, Paris, France Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France Université Pierre et Marie Curie, Paris, France Department of Biochemistry, Sargodha Medical College, Sargodha, Pakistan
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PubMed
29490275
DOI
10.1016/j.celrep.2018.02.024
Knihovny.cz E-zdroje
The age-associated deterioration in cellular and organismal functions associates with dysregulation of nutrient-sensing pathways and disabled autophagy. The reactivation of autophagic flux may prevent or ameliorate age-related metabolic dysfunctions. Non-toxic compounds endowed with the capacity to reduce the overall levels of protein acetylation and to induce autophagy have been categorized as caloric restriction mimetics (CRMs). Here, we show that aspirin or its active metabolite salicylate induce autophagy by virtue of their capacity to inhibit the acetyltransferase activity of EP300. While salicylate readily stimulates autophagic flux in control cells, it fails to further increase autophagy levels in EP300-deficient cells, as well as in cells in which endogenous EP300 has been replaced by salicylate-resistant EP300 mutants. Accordingly, the pro-autophagic activity of aspirin and salicylate on the nematode Caenorhabditis elegans is lost when the expression of the EP300 ortholog cpb-1 is reduced. Altogether, these findings identify aspirin as an evolutionary conserved CRM.
- MeSH
- acetylkoenzym A metabolismus MeSH
- Aspirin farmakologie MeSH
- autofagie účinky léků genetika MeSH
- kalorická restrikce * MeSH
- lidé MeSH
- metabolom účinky léků MeSH
- metabolomika MeSH
- myši inbrední C57BL MeSH
- nádorové buněčné linie MeSH
- protein p300 asociovaný s E1A metabolismus MeSH
- zvířata MeSH
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- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
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