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Autor
Amant, Frédéric 1 Brison, Nathalie 1 Che, Huiwen 1 Coosemans, An 1 Dehaspe, Luc 1 Dooms, Christophe 1 Fischerova, Daniela 1 Hatse, Sigrid 1 Heremans, Ruben 1 Jatsenko, Tatjana 1 Lambrechts, Diether 1 Landolfo, Chiara 1 Lenaerts, Liesbeth 1 Liekens, Lore 1 Neven, Patrick 1 Parijs, Ilse 1 Pomella, Valentina 1 Punie, Kevin 1 Tejpar, Sabine 1 Testa, Antonia Carla 1
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Pracoviště
Centre for Human Genetics University ... 1 Department of Chronic Diseases and Me... 1 Department of Development and Regener... 1 Department of General Medical Oncolog... 1 Department of Gynecology and Obstetri... 1 Department of Hematology University H... 1 Department of Human Genetics Laborato... 1 Department of Human Genetics Laborato... 1 Department of Human Genetics Laborato... 1 Department of Obstetrics and Gynaecol... 1 Department of Oncology Laboratory of ... 1 Department of Oncology Laboratory of ... 1 Department of Oncology Laboratory of ... 1 Department of Oncology Molecular Dige... 1 Department of Pneumology University H... 1 Department of Surgery Center for Gyne... 1 Department of Woman and Child Health ... 1 Multidisciplinary Breast Centre Leuve... 1
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Autor
Amant, Frédéric 1 Brison, Nathalie 1 Che, Huiwen 1 Coosemans, An 1 Dehaspe, Luc 1 Dooms, Christophe 1 Fischerova, Daniela 1 Hatse, Sigrid 1 Heremans, Ruben 1 Jatsenko, Tatjana 1 Lambrechts, Diether 1 Landolfo, Chiara 1 Lenaerts, Liesbeth 1 Liekens, Lore 1 Neven, Patrick 1 Parijs, Ilse 1 Pomella, Valentina 1 Punie, Kevin 1 Tejpar, Sabine 1 Testa, Antonia Carla 1
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Pracoviště
Centre for Human Genetics University ... 1 Department of Chronic Diseases and Me... 1 Department of Development and Regener... 1 Department of General Medical Oncolog... 1 Department of Gynecology and Obstetri... 1 Department of Hematology University H... 1 Department of Human Genetics Laborato... 1 Department of Human Genetics Laborato... 1 Department of Human Genetics Laborato... 1 Department of Obstetrics and Gynaecol... 1 Department of Oncology Laboratory of ... 1 Department of Oncology Laboratory of ... 1 Department of Oncology Laboratory of ... 1 Department of Oncology Molecular Dige... 1 Department of Pneumology University H... 1 Department of Surgery Center for Gyne... 1 Department of Woman and Child Health ... 1 Multidisciplinary Breast Centre Leuve... 1
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Open Access Digital Library od 1955-02-01
Medline Complete (EBSCOhost) od 2010-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest) od 2002-12-01 do 2022-04-30
Health & Medicine (ProQuest) od 2002-12-01 do 2022-04-30
Public Health Database (ProQuest) od 2002-12-01 do 2022-04-30
PubMed
35769009
DOI
10.1093/clinchem/hvac095
Knihovny.cz E-zdroje
BACKGROUND: Cell-free DNA (cfDNA) analysis holds great promise for non-invasive cancer screening, diagnosis, and monitoring. We hypothesized that mining the patterns of cfDNA shallow whole-genome sequencing datasets from patients with cancer could improve cancer detection. METHODS: By applying unsupervised clustering and supervised machine learning on large cfDNA shallow whole-genome sequencing datasets from healthy individuals (n = 367) and patients with different hematological (n = 238) and solid malignancies (n = 320), we identified cfDNA signatures that enabled cancer detection and typing. RESULTS: Unsupervised clustering revealed cancer type-specific sub-grouping. Classification using a supervised machine learning model yielded accuracies of 96% and 65% in discriminating hematological and solid malignancies from healthy controls, respectively. The accuracy of disease type prediction was 85% and 70% for the hematological and solid cancers, respectively. The potential utility of managing a specific cancer was demonstrated by classifying benign from invasive and borderline adnexal masses with an area under the curve of 0.87 and 0.74, respectively. CONCLUSIONS: This approach provides a generic analytical strategy for non-invasive pan-cancer detection and cancer type prediction.
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