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Autor
Bishop, Justin A 1 De Bree, Remco 1 Ferlito, Alfio 1 Feys, Simon 1 Guntinas-Lichius, Orlando 1 Hauben, Esther 1 Hellquist, Henrik 1 Hunt, Jennifer L 1 Mäkitie, Antti A 1 Quer, Miquel 1 Rinaldo, Alessandra 1 Skálová, Alena 1 Stenman, Göran 1 Strojan, Primož 1 Triantafyllou, Asterios 1 Vander Poorten, Vincent 1
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Pracoviště
Department of Head and Neck Surgical ... 1 Department of Imaging and Pathology U... 1 Department of Oncology Section Head a... 1 Department of Oncology Section Head a... 1 Department of Otorhinolaryngology Hea... 1 Department of Pathology University of... 1 Department of Pathology University of... 1 Department of Radiation Oncology Inst... 1 Epigenetics and Human Disease Laborat... 1 International Head and Neck Scientifi... 1 Multidisciplinary Salivary Gland Soci... 1 Multidisciplinary Salivary Gland Soci... 1 Multidisciplinary Salivary Gland Soci... 1 Multidisciplinary Salivary Gland Soci... 1 School of Dentistry University of Liv... 1 University of Udine School of Medicin... 1
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Autor
Bishop, Justin A 1 De Bree, Remco 1 Ferlito, Alfio 1 Feys, Simon 1 Guntinas-Lichius, Orlando 1 Hauben, Esther 1 Hellquist, Henrik 1 Hunt, Jennifer L 1 Mäkitie, Antti A 1 Quer, Miquel 1 Rinaldo, Alessandra 1 Skálová, Alena 1 Stenman, Göran 1 Strojan, Primož 1 Triantafyllou, Asterios 1 Vander Poorten, Vincent 1
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Pracoviště
Department of Head and Neck Surgical ... 1 Department of Imaging and Pathology U... 1 Department of Oncology Section Head a... 1 Department of Oncology Section Head a... 1 Department of Otorhinolaryngology Hea... 1 Department of Pathology University of... 1 Department of Pathology University of... 1 Department of Radiation Oncology Inst... 1 Epigenetics and Human Disease Laborat... 1 International Head and Neck Scientifi... 1 Multidisciplinary Salivary Gland Soci... 1 Multidisciplinary Salivary Gland Soci... 1 Multidisciplinary Salivary Gland Soci... 1 Multidisciplinary Salivary Gland Soci... 1 School of Dentistry University of Liv... 1 University of Udine School of Medicin... 1
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Vander Poorten, Vincent
Autor Vander Poorten, Vincent Department of Oncology-Section Head and Neck Oncology, Otorhinolaryngology-Head and Neck Surgery and Leuven Cancer Institute, University Hospitals Leuven, KU Leuven, Leuven, Belgium. vincent.vanderpoorten@uzleuven.be. Multidisciplinary Salivary Gland Society, Geneva, Switzerland. vincent.vanderpoorten@uzleuven.be
- Triantafyllou, Asterios
- Skálová, Alena
- Stenman, Göran
- Bishop, Justin A
- Hauben, Esther
- Hunt, Jennifer L
- Hellquist, Henrik
- Feys, Simon
- De Bree, Remco
PubMed
29761209
DOI
10.1007/s00405-018-4985-5
Knihovny.cz E-zdroje
Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to as polymorphous low-grade adenocarcinoma (PLGA), but the new WHO classification of salivary gland tumours has also included under the PAC subheading, the so-called cribriform adenocarcinoma of minor salivary glands (CAMSG). This approach raised controversy, predominantly because of possible differences in clinical behaviour. For example, PLGA (PAC, classical variant) only rarely metastasizes, whereas CAMSG often shows metastases to the neck lymph nodes. Given the controversy, this review reappraises the definition, epidemiology, clinical presentation, diagnostic work-up, genetics, treatment modalities, and prognosis of PAC of the salivary glands with a particular focus on contrasting differences with CAMSG.
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