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California Institute for Medical Rese... 1 Department of Analytical Chemistry Fa... 1 Department of Bacteriology and Mycolo... 1 Department of Biology and Ecology Fac... 1 Department of Biomedical Sciences Fac... 1 Department of Molecular Biology Publi... 1 Department of Pathology and Parasitol... 1 Division of Infectious Diseases and G... 1 Equine Clinic University of Veterinar... 1 Institute of Microbiology of the Czec... 1
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California Institute for Medical Rese... 1 Department of Analytical Chemistry Fa... 1 Department of Bacteriology and Mycolo... 1 Department of Biology and Ecology Fac... 1 Department of Biomedical Sciences Fac... 1 Department of Molecular Biology Publi... 1 Department of Pathology and Parasitol... 1 Division of Infectious Diseases and G... 1 Equine Clinic University of Veterinar... 1 Institute of Microbiology of the Czec... 1
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PubMed Central od 2015
Europe PubMed Central od 2015
ProQuest Central od 2015-06-01
Open Access Digital Library od 2015-01-01
ROAD: Directory of Open Access Scholarly Resources od 2015
PubMed
36836276
DOI
10.3390/jof9020161
Knihovny.cz E-zdroje
Invasive pulmonary aspergillosis (IPA) may be a rare cause of granulomatous pneumonia in horses. The mortality of IPA is almost 100%; direct diagnostic tools in horses are needed. Bronchoalveolar lavage fluid (BALF) and serum samples were collected from 18 horses, including individuals suffering from IPA (n = 1), equine asthma (EA, n = 12), and 5 healthy controls. Serum samples were collected from another 6 healthy controls. Samples of BALF (n = 18) were analyzed for Aspergillus spp. DNA, fungal galactomannan (GM), ferricrocin (Fc), triacetylfusarinin C (TafC), and gliotoxin (Gtx). Analysis of 24 serum samples for (1,3)-β-D-glucan (BDG) and GM was performed. Median serum BDG levels were 131 pg/mL in controls and 1142 pg/mL in IPA. Similar trends were observed in BALF samples for GM (Area under the Curve (AUC) = 0.941) and DNA (AUC = 0.941). The fungal secondary metabolite Gtx was detected in IPA BALF and lung tissue samples (86 ng/mL and 2.17 ng/mg, AUC = 1).
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Po ukončení testovacího provozu bude odkaz přesměrován adresu produkční verze portálu Medvik.