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Autor
Antonelli, Alessandro 1 Briganti, Alberto 1 Chierigo, Francesco 1 Chun, Felix K H 1 Flammia, Rocco S 1 Gallucci, Michele 1 Gandaglia, Giorgio 1 Hoeh, Benedikt 1 Hohenhorst, Lukas 1 Karakiewicz, Pierre I 1 Montorsi, Francesco 1 Nimer, Nancy 1 Panunzio, Andrea 1 Saad, Fred 1 Shariat, Shahrokh F 1 Sorce, Gabriele 1 Terrone, Carlo 1 Tian, Zhe 1 Tilki, Derya 1
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Pracoviště
Cancer Prognostics and Health Outcome... 1 Department of Maternal Child and Urol... 1 Department of Surgical and Diagnostic... 1 Department of Urology 2nd Faculty of ... 1 Department of Urology Azienda Ospedal... 1 Department of Urology Comprehensive C... 1 Department of Urology Koc University ... 1 Department of Urology University Hosp... 1 Department of Urology University Hosp... 1 Department of Urology University of T... 1 Department of Urology and Division of... 1 Departments of Urology Weill Cornell ... 1 Division of Urology Hourani Center fo... 1 Institute for Urology and Reproductiv... 1 Martini Klinik Prostate Cancer Center... 1
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Autor
Antonelli, Alessandro 1 Briganti, Alberto 1 Chierigo, Francesco 1 Chun, Felix K H 1 Flammia, Rocco S 1 Gallucci, Michele 1 Gandaglia, Giorgio 1 Hoeh, Benedikt 1 Hohenhorst, Lukas 1 Karakiewicz, Pierre I 1 Montorsi, Francesco 1 Nimer, Nancy 1 Panunzio, Andrea 1 Saad, Fred 1 Shariat, Shahrokh F 1 Sorce, Gabriele 1 Terrone, Carlo 1 Tian, Zhe 1 Tilki, Derya 1
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Pracoviště
Cancer Prognostics and Health Outcome... 1 Department of Maternal Child and Urol... 1 Department of Surgical and Diagnostic... 1 Department of Urology 2nd Faculty of ... 1 Department of Urology Azienda Ospedal... 1 Department of Urology Comprehensive C... 1 Department of Urology Koc University ... 1 Department of Urology University Hosp... 1 Department of Urology University Hosp... 1 Department of Urology University of T... 1 Department of Urology and Division of... 1 Departments of Urology Weill Cornell ... 1 Division of Urology Hourani Center fo... 1 Institute for Urology and Reproductiv... 1 Martini Klinik Prostate Cancer Center... 1
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Sorce, Gabriele
Autor Sorce, Gabriele ORCID Department of Urology and Division of Experimental Oncology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada
- Hoeh, Benedikt
- Flammia, Rocco S
- Chierigo, Francesco
- Hohenhorst, Lukas
- Panunzio, Andrea
- Nimer, Nancy
- Tian, Zhe
- Gandaglia, Giorgio
- Tilki, Derya
PubMed
35652586
DOI
10.1002/pros.24376
Knihovny.cz E-zdroje
BACKGROUND: The numbers needed to image to identify pelvic lymph node and/or distant metastases in newly diagnosed prostate cancer (PCa) patients according to risk level are unknown. METHODS: Relying on Surveillance, Epidemiology, and End Results (2010-2016), we tabulated rates and proportions of patients with (a) lymph node or (b) distant metastases according to National Comprehensive Cancer Network (NCCN) risk level and calculated the number needed to image (NNI) for both endpoints. Multivariable logistic regression analyses were performed. RESULTS: Of 145,939 newly diagnosed PCa patients assessable for analyses of pelvic lymph node metastases (cN1), 4559 (3.1%) harbored cN1 stage: 13 (0.02%), 18 (0.08%), 63 (0.3%), 512 (2.8%), and 3954 (14.9%) in low, intermediate favorable, intermediate unfavorable, high, and very high-risk levels. These resulted in NNI of 4619, 1182, 319, 35, and 7, respectively. Of 181,109 newly diagnosed PCa patients assessable for analyses of distant metastases (M1a-c ), 8920 (4.9%) harbored M1a-c stage: 50 (0.07%), 45 (0.1%), 161 (0.5%), 1290 (5.1%), and 7374 (22.0%) in low, intermediate favorable, intermediate unfavorable, high, and very high-risk. These resulted in NNI of 1347, 602, 174, 20, and 5, respectively. CONCLUSIONS: Our observations perfectly validated the NCCN recommendations for imaging in newly diagnosed high and very high-risk PCa patients. However, in unfavorable intermediate-risk PCa patients, in whom bone and soft tissue imaging is recommended, the NNI might be somewhat elevated to support routine imaging in clinical practice.
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- lidé MeSH
- lymfatické metastázy patologie MeSH
- lymfatické uzliny patologie MeSH
- nádory prostaty * patologie MeSH
- pánev patologie MeSH
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- lidé MeSH
- mužské pohlaví MeSH
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- časopisecké články MeSH
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