The pI50 index and separation coefficients of chosen 3-N,N-diethylaminophenyl-N',N'-dialkylcarbamates were determined. Index pL50 (pI50 = negative logarithm of molar concentration of inhibitor inhibiting the enzyme activity by 50%) describes the effectiveness of the inhibitor. The rate of ability of the inhibitor to pass the blood-brain barrier is usually described by the separation coefficient in a system n-octanol/water (K(ow)). Obtained results were compared with pL50 and K(ow) of Exelon, the commercially used drug against the Alzheimer's disease.
- MeSH
- acetylcholinesterasa metabolismus MeSH
- acetylthiocholin metabolismus MeSH
- alkylace MeSH
- cholinesterasové inhibitory farmakologie MeSH
- dioxany farmakologie MeSH
- Electrophorus MeSH
- financování organizované MeSH
- karbamáty farmakologie chemie MeSH
- kinetika MeSH
- molekulární modely MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH