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Pracoviště: Hopital Notre Dame Montreal

1 záznamů v Medvik Filtry

Článek

Effect of Disease-Modifying Therapy on Disability in Relapsing-Remitting Multiple Sclerosis Over 15 Years

Kalincik, Tomas
Autor Kalincik, Tomas From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia. tomas.kalincik@unimelb.edu
Diouf, Ibrahima
Autor Diouf, Ibrahima From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia
Sharmin, Sifat
Autor Sharmin, Sifat From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia
Malpas, Charles
Autor Malpas, Charles From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia
Spelman, Tim
Autor Spelman, Tim From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia
Horakova, Dana
Autor Horakova, Dana From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia
Havrdova, Eva Kubala
Autor Havrdova, Eva Kubala From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia
Trojano, Maria
Autor Trojano, Maria From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia
Izquierdo, Guillermo
Autor Izquierdo, Guillermo From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia
Lugaresi, Alessandra
Autor Lugaresi, Alessandra From CORe (T.K., I.D., S.S., C.M.), Department of Medicine, University of Melbourne MS Centre (T.K., I.D., S.S., C.M.), Department of Neurology, Royal Melbourne Hospital, Australia Karolinska Institute (T.S.), Stockholm, Sweden Department of Neuroscience (T.S., V.J., A.v.d.W., O.S., H.B.), Central Clinical School, Monash University, Melbourne Burnet Institute (T.S.), Melbourne, Australia Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), General University Hospital and Charles University in Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Hospital Universitario Virgen Macarena (G.I.), Sevilla, Spain Department of Neuroscience, Imaging and Clinical Sciences (A.L.), University "G. d'Annunzio," Chieti Department of Biomedical and Neuromotor Sciences (A.L.), University of Bologna, IRCCS Istituto delle Scienze Neurologiche di Bologna, Italy Hopital Notre Dame (A.P., M.G., P.D.), Montreal CHUM and Universite de Montreal (A.P., M.G., P.D.) CISSS Chaudière-Appalache (P.G.), Levis, Canada Department of Neurology (V.J., A.v.d.W., O.S., H.B.), Alfred Hospital, Melbourne, Australia Neuro Rive-Sud (F. Grand'Maison), Quebec, Canada Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Isfahan University of Medical Sciences (V.S.), Isfahan, Iran Amiri Hospital (R. Alroughani), Kuwait City, Kuwait Zuyderland Ziekenhuis (R.H.), Sittard, the Netherlands Medical Faculty (M. Terzi), 19 Mayis University, Samsun KTU Medical Faculty Farabi Hospital (C.B.), Karadeniz Technical University, Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle Department of Neurology (J.L.-S.), John Hunter Hospital, Newcastle, Australia UOC Neurologia (E.P.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Cliniques Universitaires Saint-Luc (V.V.P.), Brussels, Belgium University of Parma (F. Granella) C. Mondino National Neurological Institute (R.B.), Pavia Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.S.), Italy Flinders University (M. Slee), Adelaide Westmead Hospital (S.V.), Sydney, Australia Nemocnice Jihlava (R. Ampapa), Czech Republic University of Queensland (P.M.), Brisbane Royal Brisbane and Women's Hospital (P.M.), Brisbane, Australia Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain CSSS Saint-Jérôme (J.P.), Canada Hospital Universitario Donostia (J.O.), Paseo de Begiristain, San Sebastián, Spain Hospital Italiano (E.C.), Buenos Aires, Argentina Brain and Mind Centre (M.B.), University of Sydney, Australia INEBA-Institute of Neuroscience Buenos Aires (M.L.S.), Argentina Hospital de Galdakao-Usansolo (J.L.S.-M.), Galdakao, Spain Liverpool Hospital (S. Hodgkinson), Sydney, Australia Jahn Ferenc Teaching Hospital (C.R.), Budapest, Hungary Craigavon Area Hospital (S. Hughes), UK Jewish General Hospital (F.M.), Montreal, Canada Deakin University (C.S.), Geelong Monash Medical Centre (E.B.), Melbourne, Australia South East Trust (O.G.), Belfast, UK Perron Institute (A.K.), University of Western Australia, Nedlands Institute of Immunology and Infectious Diseases (A.K.), Murdoch University Sir Charles Gairdner Hospital (A.K.), Perth, Australia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Bombay Hospital Institute of Medical Sciences (B.S.), Mumbai, India St Vincents Hospital (N.S.), Fitzroy, Melbourne, Australia Veszprém Megyei Csolnoky Ferenc Kórház zrt (I.P.), Veszprem, Hungary Royal Hobart Hospital (B.T.), Australia Semmelweis University Budapest (M. Simo), Hungary Central Military Emergency University Hospital (C.-A.S.), Bucharest Titu Maiorescu University (C.-A.S.), Bucharest, Romania BAZ County Hospital (A.S.), Miskolc, Hungary and Box Hill Hospital (H.B.), Melbourne, Australia

Neurology. 2021 ; 96 (5) : e783-e797. [pub] 20201228

ISSN 1526-632X
Medvik
Zdroj

OBJECTIVE: To test the hypothesis that immunotherapy prevents long-term disability in relapsing-remitting multiple sclerosis (MS), we modeled disability outcomes in 14,717 patients. METHODS: We studied patients from MSBase followed for ≥1 year, with ≥3 visits, ≥1 visit per year, and exposed to MS therapy, and a subset of patients with ≥15-year follow-up. Marginal structural models were used to compare the cumulative hazards of 12-month confirmed increase and decrease in disability, Expanded Disability Status Scale (EDSS) step 6, and the incidence of relapses between treated and untreated periods. Marginal structural models were continuously readjusted for patient age, sex, pregnancy, date, disease course, time from first symptom, prior relapse history, disability, and MRI activity. RESULTS: A total of 14,717 patients were studied. During the treated periods, patients were less likely to experience relapses (hazard ratio 0.60, 95% confidence interval [CI] 0.43-0.82, p = 0.0016), worsening of disability (0.56, 0.38-0.82, p = 0.0026), and progress to EDSS step 6 (0.33, 0.19-0.59, p = 0.00019). Among 1,085 patients with ≥15-year follow-up, the treated patients were less likely to experience relapses (0.59, 0.50-0.70, p = 10-9) and worsening of disability (0.81, 0.67-0.99, p = 0.043). CONCLUSION: Continued treatment with MS immunotherapies reduces disability accrual by 19%-44% (95% CI 1%-62%), the risk of need of a walking aid by 67% (95% CI 41%-81%), and the frequency of relapses by 40-41% (95% CI 18%-57%) over 15 years. This study provides evidence that disease-modifying therapies are effective in improving disability outcomes in relapsing-remitting MS over the long term. CLASSIFICATION OF EVIDENCE: This study provides Class IV evidence that, for patients with relapsing-remitting MS, long-term exposure to immunotherapy prevents neurologic disability.

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