The codling moth Cydia pomonella, a major invasive pest of pome fruit, has spread around the globe in the last half century. We generated a chromosome-level scaffold assembly including the Z chromosome and a portion of the W chromosome. This assembly reveals the duplication of an olfactory receptor gene (OR3), which we demonstrate enhances the ability of C. pomonella to exploit kairomones and pheromones in locating both host plants and mates. Genome-wide association studies contrasting insecticide-resistant and susceptible strains identify hundreds of single nucleotide polymorphisms (SNPs) potentially associated with insecticide resistance, including three SNPs found in the promoter of CYP6B2. RNAi knockdown of CYP6B2 increases C. pomonella sensitivity to two insecticides, deltamethrin and azinphos methyl. The high-quality genome assembly of C. pomonella informs the genetic basis of its invasiveness, suggesting the codling moth has distinctive capabilities and adaptive potential that may explain its worldwide expansion.
- MeSH
- chromozomy hmyzu genetika MeSH
- duplikace genu MeSH
- feromony metabolismus MeSH
- genom hmyzu MeSH
- hmyzí proteiny genetika metabolismus MeSH
- insekticidy farmakologie MeSH
- jednonukleotidový polymorfismus MeSH
- můry účinky léků genetika metabolismus MeSH
- promotorové oblasti (genetika) MeSH
- receptory pachové genetika metabolismus MeSH
- rezistence k insekticidům * MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
