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Autor
Alings, Marco 1 Allaart, Cornelis P 1 Behr, Elijah R 1 Betts, Timothy R 1 Bijsterveld, Nick R 1 Boersma, Lucas V A 1 Bonnemeier, Hendrik 1 Borger van der Burg, Alida E 1 Bracke, Frank A L E 1 Brouwer, Marc A 1 Brouwer, Tom F 1 Burke, Martin C 1 Chicos, Alexandru B 1 Delnoy, Peter Paul H M 1 Dizon, Jose M 1 El-Chami, Mikhael F 1 Jansen, Ward P J 1 Kaab, Stefan 1 Knaut, Michael 1 Knops, Reinoud E 1
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Pracoviště
1st Department of Medicine University... 1 Amsterdam UMC location University of ... 1 Cardiac Electrophysiology Division De... 1 Center for Arrhythmia Care Heart and ... 1 CorVita Science Foundation Chicago IL... 1 Department of Cardiology Amphia Hospi... 1 Department of Cardiology Cardiovascul... 1 Department of Cardiology Flevoziekenh... 1 Department of Cardiology Homolka Hosp... 1 Department of Cardiology Isala Heart ... 1 Department of Cardiology OLVG Amsterd... 1 Department of Cardiology Radboud Univ... 1 Department of Cardiology St Antonius ... 1 Department of Cardiology Tergooi MC B... 1 Department of Cardiology The Heart Ce... 1 Department of Cardiology and Amsterda... 1 Department of Electrophysiology Catha... 1 Department of Electrophysiology Heart... 1 Department of Internal Medicine 1 Jen... 1 Department of Medicine 1 Ludwig Maxim... 1
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Autor
Alings, Marco 1 Allaart, Cornelis P 1 Behr, Elijah R 1 Betts, Timothy R 1 Bijsterveld, Nick R 1 Boersma, Lucas V A 1 Bonnemeier, Hendrik 1 Borger van der Burg, Alida E 1 Bracke, Frank A L E 1 Brouwer, Marc A 1 Brouwer, Tom F 1 Burke, Martin C 1 Chicos, Alexandru B 1 Delnoy, Peter Paul H M 1 Dizon, Jose M 1 El-Chami, Mikhael F 1 Jansen, Ward P J 1 Kaab, Stefan 1 Knaut, Michael 1 Knops, Reinoud E 1
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Pracoviště
1st Department of Medicine University... 1 Amsterdam UMC location University of ... 1 Cardiac Electrophysiology Division De... 1 Center for Arrhythmia Care Heart and ... 1 CorVita Science Foundation Chicago IL... 1 Department of Cardiology Amphia Hospi... 1 Department of Cardiology Cardiovascul... 1 Department of Cardiology Flevoziekenh... 1 Department of Cardiology Homolka Hosp... 1 Department of Cardiology Isala Heart ... 1 Department of Cardiology OLVG Amsterd... 1 Department of Cardiology Radboud Univ... 1 Department of Cardiology St Antonius ... 1 Department of Cardiology Tergooi MC B... 1 Department of Cardiology The Heart Ce... 1 Department of Cardiology and Amsterda... 1 Department of Electrophysiology Catha... 1 Department of Electrophysiology Heart... 1 Department of Internal Medicine 1 Jen... 1 Department of Medicine 1 Ludwig Maxim... 1
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- Publikační typ
- Check Tag
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- Jazyk
- Země
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- Vlastník
- Knops, Reinoud E
- Pepplinkhuizen, Shari
- Delnoy, Peter Paul H M
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Boersma, Lucas V A
Autor Boersma, Lucas V A ORCID Amsterdam UMC location University of Amsterdam, Heart Center, Department of Cardiology, Amsterdam Cardiovascular Sciences Heart failure & Arrhythmias, Meibergdreef 9, 1105 AZ Amsterdam, the Netherlands Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands
- Kuschyk, Juergen
- El-Chami, Mikhael F
- Bonnemeier, Hendrik
- Behr, Elijah R
- Brouwer, Tom F
- Kaab, Stefan
Open Access Digital Library od 1996-01-01
PubMed
36030464
DOI
10.1093/eurheartj/ehac496
Knihovny.cz E-zdroje
BACKGROUND: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is developed to overcome lead-related complications and systemic infections, inherent to transvenous ICD (TV-ICD) therapy. The PRAETORIAN trial demonstrated that the S-ICD is non-inferior to the TV-ICD with regard to the combined primary endpoint of inappropriate shocks and complications. This prespecified secondary analysis evaluates all complications in the PRAETORIAN trial. METHODS AND RESULTS: The PRAETORIAN trial is an international, multicentre, randomized trial in which 849 patients with an indication for ICD therapy were randomized to receive an S- ICD (N = 426) or TV-ICD (N = 423) and followed for a median of 49 months. Endpoints were device-related complications, lead-related complications, systemic infections, and the need for invasive interventions. Thirty-six device-related complications occurred in 31 patients in the S-ICD group of which bleedings were the most frequent. In the TV-ICD group, 49 complications occurred in 44 patients of which lead dysfunction was most frequent (HR: 0.69; P = 0.11). In both groups, half of all complications were within 30 days after implantation. Lead-related complications and systemic infections occurred significantly less in the S-ICD group compared with the TV-ICD group (P < 0.001, P = 0.03, respectively). Significantly more complications required invasive interventions in the TV-ICD group compared with the S-ICD group (8.3% vs. 4.3%, HR: 0.59; P = 0.047). CONCLUSION: This secondary analysis shows that lead-related complications and systemic infections are more prevalent in the TV-ICD group compared with the S-ICD group. In addition, complications in the TV-ICD group were more severe as they required significantly more invasive interventions. This data contributes to shared decision-making in clinical practice.
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