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CIBERobn Physiopathology of Obesity a... 1 Centre for Exercise Nutrition and Hea... 1 Department of Endocrinology Diabetes ... 1 Department of Human Biology NUTRIM Sc... 1 Department of Pharmacology and Toxico... 1 Escuela Internacional de Doctorado de... 1 Medicine and Psychology School Autono... 1 Navarra's Health Research Institute P... 1 Nuffield Department of Primary Care H... 1 Obesity Management Centre Institute o... 1 Obesity and Nutrition Science Novo No... 1 Precision Nutrition Program IMDEA Foo... 1
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CIBERobn Physiopathology of Obesity a... 1 Centre for Exercise Nutrition and Hea... 1 Department of Endocrinology Diabetes ... 1 Department of Human Biology NUTRIM Sc... 1 Department of Pharmacology and Toxico... 1 Escuela Internacional de Doctorado de... 1 Medicine and Psychology School Autono... 1 Navarra's Health Research Institute P... 1 Nuffield Department of Primary Care H... 1 Obesity Management Centre Institute o... 1 Obesity and Nutrition Science Novo No... 1 Precision Nutrition Program IMDEA Foo... 1
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BioMedCentral Open Access od 2004
Directory of Open Access Journals od 2004
Free Medical Journals od 2004
PubMed Central od 2004
Europe PubMed Central od 2004
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ROAD: Directory of Open Access Scholarly Resources od 2004
Springer Journals Complete - Open Access od 2004-12-01
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PubMed
36261843
DOI
10.1186/s12986-022-00707-y
Knihovny.cz E-zdroje
BACKGROUND AND AIM: The role of dietary protein and glycemic index on insulin resistance (based on TyG index) within a nutritional program for weight loss and weight maintenance was examined. METHODS: This study analyzed 744 adults with overweight/obesity within the DIOGenes project. Patients who lost at least 8% of their initial weight (0-8 weeks) after a low-calorie diet (LCD) were randomly assigned to one of five ad libitum diets designed for weight maintenance (8-34 weeks): high/low protein (HP/LP) and high/low glycemic index (HGI/LGI), plus a control. The complete nutritional program (0-34 weeks) included both LCD plus the randomized diets intervention. The TyG index was tested as marker of body mass composition and insulin resistance. RESULTS: In comparison with the LP/HGI diet, the HP/LGI diet induced a greater BMI loss (p < 0.05). ∆TyG was positively associated with resistance to BMI loss (β = 0.343, p = 0.042) during the weight maintenance stage. In patients who followed the HP/LGI diet, TyG (after LCD) correlated with greater BMI loss in the 8-34 weeks period (r = -0.256; p < 0.05) and during the 0-34 weeks intervention (r = -0.222, p < 0.05) periods. ΔTyG1 value was associated with ΔBMI2 (β = 0.932; p = 0.045) concerning the HP/LGI diet. CONCLUSIONS: A HP/LGI diet is beneficial not only for weight maintenance after a LCD, but is also related to IR amelioration as assessed by TyG index changes. Registration Clinical Trials NCT00390637.
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