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Autor
Andršová, Irena 1 Bauer, Axel 1 Britton, Annie 1 Franz, Michael R 1 Friede, Tim 1 Hnatkova, Katerina 1 Huikuri, Heikki V 1 Junttila, Juhani 1 Malik, Marek 1 Novotný, Tomáš 1 Reichlin, Tobias 1 Schlögl, Simon 1 Schmidt, Georg 1 Shipley, Martin 1 Sprenkeler, David J 1 Sticherling, Christian 1 Vandenberk, Bert 1 Vos, Marc A 1 Willems, Rik 1 Zabel, Markus 1
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Pracoviště
Department of Cardiology Inselspital ... 1 Department of Cardiology University H... 1 Department of Cardiology and Pneumolo... 1 Department of Cardiovascular Sciences... 1 Department of Internal Medicine and C... 1 Department of Internal Medicine and C... 1 Department of Medical Physiology Univ... 1 Department of Medical Statistics Univ... 1 German Center for Cardiovascular Rese... 1 German Center of Cardiovascular Resea... 1 Klinikum rechts der Isar Technical Un... 1 Medical Research Center Oulu Universi... 1 National Heart and Lung Institute Imp... 1 Research Department of Epidemiology a... 1 University Hospital for Internal Medi... 1 Veteran Affairs and Georgetown Univer... 1
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Autor
Andršová, Irena 1 Bauer, Axel 1 Britton, Annie 1 Franz, Michael R 1 Friede, Tim 1 Hnatkova, Katerina 1 Huikuri, Heikki V 1 Junttila, Juhani 1 Malik, Marek 1 Novotný, Tomáš 1 Reichlin, Tobias 1 Schlögl, Simon 1 Schmidt, Georg 1 Shipley, Martin 1 Sprenkeler, David J 1 Sticherling, Christian 1 Vandenberk, Bert 1 Vos, Marc A 1 Willems, Rik 1 Zabel, Markus 1
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Pracoviště
Department of Cardiology Inselspital ... 1 Department of Cardiology University H... 1 Department of Cardiology and Pneumolo... 1 Department of Cardiovascular Sciences... 1 Department of Internal Medicine and C... 1 Department of Internal Medicine and C... 1 Department of Medical Physiology Univ... 1 Department of Medical Statistics Univ... 1 German Center for Cardiovascular Rese... 1 German Center of Cardiovascular Resea... 1 Klinikum rechts der Isar Technical Un... 1 Medical Research Center Oulu Universi... 1 National Heart and Lung Institute Imp... 1 Research Department of Epidemiology a... 1 University Hospital for Internal Medi... 1 Veteran Affairs and Georgetown Univer... 1
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Open Access Digital Library od 1996-01-01
PubMed
35187560
DOI
10.1093/eurheartj/ehac085
Knihovny.cz E-zdroje
AIMS: Fragmented QRS complex with visible notching on standard 12-lead electrocardiogram (ECG) is understood to represent depolarization abnormalities and to signify risk of cardiac events. Depolarization abnormalities with similar prognostic implications likely exist beyond visual recognition but no technology is presently suitable for quantification of such invisible ECG abnormalities. We present such a technology. METHODS AND RESULTS: A signal processing method projects all ECG leads of the QRS complex into optimized three perpendicular dimensions, reconstructs the ECG back from this three-dimensional projection, and quantifies the difference (QRS 'micro'-fragmentation, QRS-μf) between the original and reconstructed signals. QRS 'micro'-fragmentation was assessed in three different populations: cardiac patients with automatic implantable cardioverter-defibrillators, cardiac patients with severe abnormalities, and general public. The predictive value of QRS-μf for mortality was investigated both univariably and in multivariable comparisons with other risk factors including visible QRS 'macro'-fragmentation, QRS-Mf. The analysis was made in a total of 7779 subjects of whom 504 have not survived the first 5 years of follow-up. In all three populations, QRS-μf was strongly predictive of survival (P < 0.001 univariably, and P < 0.001 to P = 0.024 in multivariable regression analyses). A similar strong association with outcome was found when dichotomizing QRS-μf prospectively at 3.5%. When QRS-μf was used in multivariable analyses, QRS-Mf and QRS duration lost their predictive value. CONCLUSION: In three populations with different clinical characteristics, QRS-μf was a powerful mortality risk factor independent of several previously established risk indices. Electrophysiologic abnormalities that contribute to increased QRS-μf values are likely responsible for the predictive power of visible QRS-Mf.
- MeSH
- elektrokardiografie * metody MeSH
- lidé MeSH
- prediktivní hodnota testů MeSH
- prognóza MeSH
- rizikové faktory MeSH
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- časopisecké články MeSH
- práce podpořená grantem MeSH
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