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Autor
Beer, Benedikt N 1 Bertoldi, Letizia Fausta 1 Besch, Lisa 1 Blankenberg, Stefan 1 Dauw, Jeroen 1 Dettling, Angela 1 Dindane, Zouhir 1 Eckner, Dennis 1 Eitel, Ingo 1 Graf, Tobias 1 Gustafsson, Finn 1 Horn, Patrick 1 Jozwiak-Nozdrzykowska, Joanna 1 Kelham, Matthew 1 Kellner, Caroline 1 Kirchhof, Paulus 1 Kluge, Stefan 1 Landmesser, Ulf 1 Linke, Axel 1 Luedike, Peter 1
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Pracoviště
Anesthesia and Intensive Care Fondazi... 1 Cardio Center Humanitas Clinical and ... 1 Center for Population Health Innovati... 1 Department of Cardiology AZ Sint Luca... 1 Department of Cardiology Charité Univ... 1 Department of Cardiology IKEM Prague ... 1 Department of Cardiology Paracelsus M... 1 Department of Cardiology University H... 1 Department of Cardiology and Angiolog... 1 Department of Cardiology and Vascular... 1 Department of Cardiothoracic Surgery ... 1 Department of Cardiothoracic and Vasc... 1 Department of Clinical Surgical Diagn... 1 Department of Intensive Care Medicine... 1 Department of Internal Medicine 1 Uni... 1 Department of Internal Medicine 1 Uni... 1 Department of Internal Medicine and C... 1 Department of Medicine 1 University H... 1 Department of Perioperative Medicine ... 1 Division of Cardiology Pulmonology an... 1
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Autor
Beer, Benedikt N 1 Bertoldi, Letizia Fausta 1 Besch, Lisa 1 Blankenberg, Stefan 1 Dauw, Jeroen 1 Dettling, Angela 1 Dindane, Zouhir 1 Eckner, Dennis 1 Eitel, Ingo 1 Graf, Tobias 1 Gustafsson, Finn 1 Horn, Patrick 1 Jozwiak-Nozdrzykowska, Joanna 1 Kelham, Matthew 1 Kellner, Caroline 1 Kirchhof, Paulus 1 Kluge, Stefan 1 Landmesser, Ulf 1 Linke, Axel 1 Luedike, Peter 1
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Pracoviště
Anesthesia and Intensive Care Fondazi... 1 Cardio Center Humanitas Clinical and ... 1 Center for Population Health Innovati... 1 Department of Cardiology AZ Sint Luca... 1 Department of Cardiology Charité Univ... 1 Department of Cardiology IKEM Prague ... 1 Department of Cardiology Paracelsus M... 1 Department of Cardiology University H... 1 Department of Cardiology and Angiolog... 1 Department of Cardiology and Vascular... 1 Department of Cardiothoracic Surgery ... 1 Department of Cardiothoracic and Vasc... 1 Department of Clinical Surgical Diagn... 1 Department of Intensive Care Medicine... 1 Department of Internal Medicine 1 Uni... 1 Department of Internal Medicine 1 Uni... 1 Department of Internal Medicine and C... 1 Department of Medicine 1 University H... 1 Department of Perioperative Medicine ... 1 Division of Cardiology Pulmonology an... 1
- Formát
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- Kategorie
- Jazyk
- Země
- Časopis/zdroj
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- Sundermeyer, Jonas
- Kellner, Caroline
- Beer, Benedikt N
- Besch, Lisa
- Dettling, Angela
- Bertoldi, Letizia Fausta
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Blankenberg, Stefan
Autor Blankenberg, Stefan Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Hamburg, Germany Center for Population Health Innovation (POINT), University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Dauw, Jeroen
- Dindane, Zouhir
- Eckner, Dennis
AIMS: Heart failure-related cardiogenic shock (HF-CS) accounts for a significant proportion of CS cases. Whether patients with de novo HF and those with acute-on-chronic HF in CS differ in clinical characteristics and outcome remains unclear. The aim of this study was to evaluate differences in clinical presentation and mortality between patients with de novo and acute-on-chronic HF-CS. METHODS AND RESULTS: In this international observational study, patients with HF-CS from 16 tertiary care centres in five countries were enrolled between 2010 and 2021. To investigate differences in clinical presentation and 30-day mortality, adjusted logistic/Cox regression models were fitted. Patients (n = 1030) with HF-CS were analysed, of whom 486 (47.2%) presented with de novo HF-CS and 544 (52.8%) with acute-on-chronic HF-CS. Traditional markers of CS severity (e.g. blood pressure, heart rate and lactate) as well as use of treatments were comparable between groups. However, patients with acute-on-chronic HF-CS were more likely to have a higher CS severity and also a higher mortality risk, after adjusting for relevant confounders (de novo HF 45.5%, acute-on-chronic HF 55.9%, adjusted hazard ratio 1.38, 95% confidence interval 1.10-1.72, p = 0.005). CONCLUSION: In this large HF-CS cohort, acute-on-chronic HF-CS was associated with more severe CS and higher mortality risk compared to de novo HF-CS, although traditional markers of CS severity and use of treatments were comparable. These findings highlight the vast heterogeneity of patients with HF-CS, emphasize that HF chronicity is a relevant disease modifier in CS, and indicate that future clinical trials should account for this.
- MeSH
- kardiogenní šok * etiologie MeSH
- lidé MeSH
- mortalita v nemocnicích MeSH
- prognóza MeSH
- srdeční selhání * MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
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