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Autor
Abraham, Theodore P 1 Arad, Michael 1 Cardim, Nuno 1 Choudhury, Lubna 1 Coats, Caroline J 1 Düngen, Hans-Dirk 1 Garcia-Pavia, Pablo 1 Hagège, Albert A 1 Heitner, Stephen B 1 Jacoby, Daniel L 1 Kupfer, Stuart 1 Lee, Matthew M Y 1 Lewis, Gregory D 1 Ma, Chang-Sheng 1 Malik, Fady I 1 Maron, Martin S 1 Masri, Ahmad 1 Meng, Lisa 1 Michels, Michelle 1 Olivotto, Iacopo 1
- Organizace
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Pracoviště
Beijing Anzhen Hospital Capital Medic... 1 Charité Campus Virchow Klinikum Berli... 1 Cytokinetics Incorporated South San F... 1 Department of Cardiology Copenhagen U... 1 Département de Cardiologie Assistance... 1 Erasmus University Medical Center Rot... 1 Hospital Da Luz Lisbon Portugal 1 Hospital Universitario Puerta de Hier... 1 Hypertrophic Cardiomyopathy Center at... 1 Leviev Heart Center Sheba Medical Cen... 1 Massachusetts General Hospital Boston... 1 Meyer Children's Hospital Istituto di... 1 Narodowy Instytut Kardiologii Warsaw ... 1 Northwestern University Feinberg Scho... 1 Oregon Health and Science University ... 1 Radcliffe Department of Medicine Univ... 1 School of Cardiovascular and Metaboli... 1 Section of Forensic Genetics Departme... 1 Tel Aviv University Medical School Is... 1 UCSF Medical Center San Francisco Cal... 1
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Autor
Abraham, Theodore P 1 Arad, Michael 1 Cardim, Nuno 1 Choudhury, Lubna 1 Coats, Caroline J 1 Düngen, Hans-Dirk 1 Garcia-Pavia, Pablo 1 Hagège, Albert A 1 Heitner, Stephen B 1 Jacoby, Daniel L 1 Kupfer, Stuart 1 Lee, Matthew M Y 1 Lewis, Gregory D 1 Ma, Chang-Sheng 1 Malik, Fady I 1 Maron, Martin S 1 Masri, Ahmad 1 Meng, Lisa 1 Michels, Michelle 1 Olivotto, Iacopo 1
- Organizace
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Pracoviště
Beijing Anzhen Hospital Capital Medic... 1 Charité Campus Virchow Klinikum Berli... 1 Cytokinetics Incorporated South San F... 1 Department of Cardiology Copenhagen U... 1 Département de Cardiologie Assistance... 1 Erasmus University Medical Center Rot... 1 Hospital Da Luz Lisbon Portugal 1 Hospital Universitario Puerta de Hier... 1 Hypertrophic Cardiomyopathy Center at... 1 Leviev Heart Center Sheba Medical Cen... 1 Massachusetts General Hospital Boston... 1 Meyer Children's Hospital Istituto di... 1 Narodowy Instytut Kardiologii Warsaw ... 1 Northwestern University Feinberg Scho... 1 Oregon Health and Science University ... 1 Radcliffe Department of Medicine Univ... 1 School of Cardiovascular and Metaboli... 1 Section of Forensic Genetics Departme... 1 Tel Aviv University Medical School Is... 1 UCSF Medical Center San Francisco Cal... 1
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Patients with obstructive hypertrophic cardiomyopathy (oHCM) have increased risk of arrhythmia, stroke, heart failure, and sudden death. Contemporary management of oHCM has decreased annual hospitalization and mortality rates, yet patients have worsening health-related quality of life due to impaired exercise capacity and persistent residual symptoms. Here we consider the design of clinical trials evaluating potential oHCM therapies in the context of SEQUOIA-HCM (Safety, Efficacy, and Quantitative Understanding of Obstruction Impact of Aficamten in HCM). This large, phase 3 trial is now fully enrolled (N = 282). Baseline characteristics reflect an ethnically diverse population with characteristics typical of patients encountered clinically with substantial functional and symptom burden. The study will assess the effect of aficamten vs placebo, in addition to standard-of-care medications, on functional capacity and symptoms over 24 weeks. Future clinical trials could model the approach in SEQUOIA-HCM to evaluate the effect of potential therapies on the burden of oHCM. (Safety, Efficacy, and Quantitative Understanding of Obstruction Impact of Aficamten in HCM [SEQUOIA-HCM]; NCT05186818).
- MeSH
- hypertrofická kardiomyopatie * komplikace MeSH
- kvalita života MeSH
- lidé MeSH
- sekvoj * MeSH
- srdeční selhání * farmakoterapie MeSH
- tolerance zátěže MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
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