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Pracoviště: The University of Texas Health Science Center a...

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Článek

Treatment Response Score to Glatiramer Acetate or Interferon Beta-1a

Bovis, Francesca
Autor Bovis, Francesca From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy
Kalincik, Tomas
Autor Kalincik, Tomas From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy
Lublin, Fred
Autor Lublin, Fred From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy
Cutter, Gary
Autor Cutter, Gary From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy
Malpas, Charles
Autor Malpas, Charles From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy
Horakova, Dana
Autor Horakova, Dana From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy
Havrdova, Eva Kubala
Autor Havrdova, Eva Kubala From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy
Trojano, Maria
Autor Trojano, Maria From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy
Prat, Alexandre
Autor Prat, Alexandre From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy
Girard, Marc
Autor Girard, Marc From the Department of Health Sciences (DISSAL) (F.B., M.P.S.), University of Genoa, Italy CORe (T.K., C.M.), Department of Medicine, University of Melbourne, Australia Department of Neurology (F.L.), Icahn School of Medicine at Mount Sinai, New York, NY Department of Biostatistics (G.C.), University of Alabama at Birmingham Department of Neurology and Center for Clinical Neuroscience (D.H., E.K.H.), First Medical Faculty, Charles University, Prague, Czech Republic Department of Basic Medical Sciences, Neuroscience and Sense Organs (M. Trojano), University of Bari, Italy Department of Neuroscience (A.P., M.G., P.D.), Faculty of Medicine, Université de Montréal, Quebec, Canada Department of Neuroscience, Imaging, and Clinical Sciences (M.O.), University G. d'Annunzio, Chieti IRCCS Istituto delle Scienze Neurologiche di Bologna (A.L.) Dipartimento di Scienze Biomediche e Neuromotorie (A.L.), Università di Bologna, Italy Hospital Universitario Virgen Macarena (G. Izquierdo. S.E.), Sevilla, Spain Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia" (F.P.), University of Catania, Italy Ondokuz Mayis University (M. Terzi), Department of Neurology, Samsun, Turkey CISSS Chaudi're-Appalache (P.G.), Centre-Hospitalier, Levis, Quebec, Canada IRCCS Mondino Foundation (R.B.), Pavia Department of Neuroscience (P.S., D.F.), Azienda Ospedaliera Universitaria, Modena, Italy Department of Neurology (S.O.), Dokuz Eylul University, Izmir, Turkey Ospedali Riuniti di Salerno (G. Iuliano), Salerno, Italy Department of Neurology (C.B.), Karadeniz Technical University, Trabzon, Turkey Department of Neurology (R.H.), Zuyderland Medical Center, Sittard, the Netherlands Neuro Rive-Sud (F.G.), Hôpital Charles LeMoyne, Greenfield Park, Quebec, Canada Clinico San Carlos (C.O.-G), Madrid, Spain Cliniques Universitaires Saint-Luc (V.v.P.) Université Catholique de Louvain (V.v.P.), Brussels, Belgium UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy Kommunehospitalet (T.P.), Arhus C, Denmark Koc University (A.A.), School of Medicine Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey Hospital Germans Trias i Pujol (C.R.-T.), Badalona, Spain University of Queensland (P.M.), Brisbane, Australia Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Central Clinical School (H.B.), Monash University, Melbourne, Australia The University of Texas Health Science Center at Houston (J.S.W.) Rehabilitation Unit (C.S.), "Mons. L. Novarese" Hospital, Moncrivello and IRCCS Ospedale Policlinico San Martino (M.P.S.), Genoa, Italy

Neurology. 2021 ; 96 (2) : e214-e227. [pub] 20201006

ISSN 1526-632X
Medvik
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OBJECTIVE: To compare the effectiveness of glatiramer acetate (GA) vs intramuscular interferon beta-1a (IFN-β-1a), we applied a previously published statistical method aimed at identifying patients' profiles associated with efficacy of treatments. METHODS: Data from 2 independent multiple sclerosis datasets, a randomized study (the Combination Therapy in Patients With Relapsing-Remitting Multiple Sclerosis [CombiRx] trial, evaluating GA vs IFN-β-1a) and an observational cohort extracted from MSBase, were used to build and validate a treatment response score, regressing annualized relapse rates (ARRs) on a set of baseline predictors. RESULTS: The overall ARR ratio of GA to IFN-β-1a in the CombiRx trial was 0.72. The response score (made up of a linear combination of age, sex, relapses in the previous year, disease duration, and Expanded Disability Status Scale score) detected differential response of GA vs IFN-β-1a: in the trial, patients with the largest benefit from GA vs IFN-β-1a (lower score quartile) had an ARR ratio of 0.40 (95% confidence interval [CI] 0.25-0.63), those in the 2 middle quartiles of 0.90 (95% CI 0.61-1.34), and those in the upper quartile of 1.14 (95% CI 0.59-2.18) (heterogeneity p = 0.012); this result was validated on MSBase, with the corresponding ARR ratios of 0.58 (95% CI 0.46-0.72), 0.92 (95% CI 0.77-1.09,) and 1.29 (95% CI 0.97-1.71); heterogeneity p < 0.0001). CONCLUSIONS: We demonstrate the possibility of a criterion, based on patients' characteristics, to choose whether to treat with GA or IFN-β-1a. This result, replicated on an independent real-life cohort, may have implications for clinical decisions in everyday clinical practice.

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