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Pracoviště: Translational Neuroimmunology Group Kids Neuros...

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Článek

Risk of Seizure Recurrence Due to Autoimmune Encephalitis With NMDAR, LGI1, CASPR2, and GABABR Antibodies: Implications for Return to Driving

Rada, Anna
Autor Rada, Anna ORCID From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany
Hagemann, Anne
Autor Hagemann, Anne ORCID From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany
Aaberg Poulsen, Charlotte
Autor Aaberg Poulsen, Charlotte From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany
Baumgartner, Tobias
Autor Baumgartner, Tobias From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany
Berki, Timea
Autor Berki, Timea From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany
Blaabjerg, Morten
Autor Blaabjerg, Morten From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany
Brenner, Juliette
Autor Brenner, Juliette ORCID From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany
Britton, Jeffrey W
Autor Britton, Jeffrey W ORCID From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany
Christiana, Andrew
Autor Christiana, Andrew ORCID From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany
Ciano-Petersen, Nicolás L
Autor Ciano-Petersen, Nicolás L ORCID From the Department of Epileptology (Krankenhaus Mara) (A.R., C.G.B., U.S.), Medical School, Bielefeld University, Campus Bielefeld-Bethel Society for Epilepsy Research (A.H.), Bielefeld, Germany Department of Neurology (C.A.P., M.B.), Odense University Hospital Department of Clinical Research (M.B.), University of Southern Denmark, Odense, Denmark Department of Epileptology (T. Baumgartner, R.S.), University Hospital Bonn, Germany Department of Immunology and Biotechnology (T. Berki), University of Pécs, Medical School, Hungary Department of Neurology (J.B., Y.C., M.J.T., J.M.V.), Erasmus Medical Center, Rotterdam, Zuid-Holland, the Netherlands Division of Epilepsy (J.W.B., K.M.S.), Department of Neurology, Mayo Clinic, Rochester, MN NYU Comprehensive Epilepsy Center (A.C., C. Steriade), New York French Reference Center on Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis (N.L.C.-P., A.F., J. Honnorat, S.M.-C.), Hospices Civils de Lyon, Hôpital Neurologique, UMR MELIS Inserm 1314 / CNRS 5284, Université Claude Bernard Lyon1, France Department of Neurology (M.E., P.M.), Second Faculty of Medicine, Charles University, Motol University Hospital, Prague, Czech Republic Department of Neurology (A.R.F., J. Hébert), Columbia University Irving Medical Center (CUIMC)/New York Presbyterian Hospital, New York Department of Neurology (Z. Hayden), Medical School, University of Pécs, Pécs, Hungary Division of Neurology (J. Hébert), University of Toronto, Ontario, Canada Epilepsy-Center Berlin-Brandenburg (M.H., M.I.-F.), Department of Neurology, Charité - Universitätsmedizin Berlin, Germany Department of Neurology (Z. Hong), West China Hospital, Sichuan University, Chengdu, China Oxford Autoimmune Neurology Group (S.R.I., S.R., C.E.U.), Nuffield Department of Clinical Neurosciences, Oxford, United Kingdom Department of Neurology and Neurosciences (S.R.I.), Mayo Clinic, Jacksonville, FL Department of Neurology with Institute of Translational Neurology (S.K., C. Strippel), University Hospital Münster, Germany Translational Neuroimmunology Group (S.R.), Kids Neuroscience Centre, Children's Hospital at Westmead Faculty of Medicine and Health, University of Sydney Department of Neurology, Concord Hospital, Sydney, Australia Division of Neurology (C.E.U.), Department of Medicine, University of British Columbia, Vancouver, Canada and Laboratory Krone (C.G.B.), Bad Salzuflen, Germany

Neurology® neuroimmunology & neuroinflammation. 2024 ; 11 (4) : e200225. [pub] 20240604

Neurol Neuroimmunol Neuroinflamm
ISSN 2332-7812
Medvik
Zdroj

BACKGROUND AND OBJECTIVES: Patients with ongoing seizures are usually not allowed to drive. The prognosis for seizure freedom is favorable in patients with autoimmune encephalitis (AIE) with antibodies against NMDA receptor (NMDAR), leucine-rich glioma-inactivated 1 (LGI1), contactin-associated protein-like 2 (CASPR2), and the gamma-aminobutyric-acid B receptor (GABABR). We hypothesized that after a seizure-free period of 3 months, patients with AIE have a seizure recurrence risk of <20% during the subsequent 12 months. This would render them eligible for noncommercial driving according to driving regulations in several countries. METHODS: This retrospective multicenter cohort study analyzed follow-up data from patients aged 15 years or older with seizures resulting from NMDAR-, LGI1-, CASPR2-, or GABABR-AIE, who had been seizure-free for ≥3 months. We used Kaplan-Meier (KM) estimates for the seizure recurrence risk at 12 months for each antibody group and tested for the effects of potential covariates with regression models. RESULTS: We included 383 patients with NMDAR-, 440 with LGI1-, 114 with CASPR2-, and 44 with GABABR-AIE from 14 international centers. After being seizure-free for 3 months after an initial seizure period, we calculated the probability of remaining seizure-free for another 12 months (KM estimate) as 0.89 (95% confidence interval [CI] 0.85-0.92) for NMDAR, 0.84 (CI 0.80-0.88) for LGI1, 0.82 (CI 0.75-0.90) for CASPR2, and 0.76 (CI 0.62-0.93) for GABABR. DISCUSSION: Taking a <20% recurrence risk within 12 months as sufficient, patients with NMDAR-AIE and LGI1-AIE could be considered eligible for noncommercial driving after having been seizure-free for 3 months.

MeSH
autoprotilátky * krev MeSH
dospělí MeSH
encefalitida * imunologie MeSH
Hashimotova nemoc imunologie krev MeSH
intracelulární signální peptidy a proteiny * imunologie MeSH
kohortové studie MeSH
lidé středního věku MeSH
lidé MeSH
membránové proteiny * imunologie MeSH
mladiství MeSH
mladý dospělý MeSH
následné studie MeSH
proteiny nervové tkáně * imunologie MeSH
proteiny imunologie MeSH
receptory GABA-B * imunologie MeSH
receptory N-methyl-D-aspartátu imunologie MeSH
recidiva * MeSH
retrospektivní studie MeSH
senioři MeSH
záchvaty etiologie imunologie MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mladiství MeSH
mladý dospělý MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
multicentrická studie MeSH

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