The aim of the present study was to compare the behavioral effects of modafinil, an atypical psychostimulatory acting and cognitive-function improving drug, with the effects of the psychostimulants methamphetamine (MET) and MDMA (3,4-methylenedioxymethamphetamine, or "ecstasy") in a model of mouse agonistic behavior. This model enables the observation of ethologically well-defined sociable, timid, aggressive, and locomotor behavioral acts and postures. Singly-housed male mice (isolates) were separated into 4 groups. The observations were performed in 4 sessions, 1 week apart. In each interaction, singly-housed mice were paired with non-aggressive group-housed partners for 4 min in a neutral environment. The isolates received, in a Latin square design, either a) a vehicle or modafinil at doses 2.0, 10.0, or 50.0 mg/kg; or b) a vehicle or MET at doses 1.0, 5.0, or 10.0 mg/kg; or c) a vehicle or MDMA at doses 2.5, 10.0, or 30.0 mg/kg. The isolates were categorized as timid or aggressive according to their behavior in the control interaction (vehicle pre-treatment). Elements of locomotor, sociable, aggressive, and timid behavior were evaluated (one-way ANOVA). In the aggressive mice, no change in the sum of aggressive behavior was measured following modafinil administration, while both methamphetamine and MDMA produced dose-dependent inhibition of aggression (p<0.01). The substantial difference in the tested drug effects on agonistic behavior was an increased occurrence of sociable acts (p<0.01) accompanied by a simultaneous increase of timid acts (p<0.01) recorded after MDMA, but not after modafinil or methamphetamine administration. In the timid mice, at least some doses of modafinil decreased timidity (p<0.01) and increased aggression (p<0.01) with no effect on sociability. Administration of MDMA increased timid activities (p<0.01). Both MDMA and MET decreased sociability (p<0.01).
- MeSH
- agrese MeSH
- benzhydrylové sloučeniny farmakologie MeSH
- chování zvířat účinky léků MeSH
- methamfetamin farmakologie MeSH
- myši MeSH
- N-methyl-3,4-methylendioxyamfetamin farmakologie MeSH
- stimulanty centrálního nervového systému farmakologie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Klíčová slova
- behaviorální senzitizace,
- MeSH
- behaviorální symptomy farmakoterapie MeSH
- benzhydrylové sloučeniny * terapeutické užití MeSH
- chování MeSH
- experimenty na zvířatech MeSH
- financování organizované MeSH
- myši MeSH
- poruchy cirkadiánního rytmu (spánek) * farmakoterapie MeSH
- poruchy spojené s užíváním psychoaktivních látek * MeSH
- psychologické modely MeSH
- psychotropní léky farmakokinetika farmakologie MeSH
- sociální chování MeSH
- statistika jako téma MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
