The environmental occurrence of antimicrobial pharmaceuticals and antibiotic resistant bacteria and antibiotic resistant genes has become a global phenomenon and a multifaceted threat. Integrated actions of many parties are needed to prevent further aggravation of the problem. Well-directed actions require clear understanding of the problem, which can be ensured by frequent revaluation of the existing knowledge and disseminating it among relevant audiences. The goal of this review paper is to discuss the occurrence and abundance of antimicrobial pharmaceuticals in the aquatic environment in context of adverse effects caused directly by these substances and the threat associated with the antibiotics resistance phenomenon. Several classes of antimicrobial pharmaceuticals (aminoglycosides, β-lactams, glycopeptides, macrolides, fluoroquinolones, sulfonamides and trimethoprim, tetracyclines) have been selected to illustrate their sources, environmental abundance, degradation routes (transformation products) and environmental implications including their ecotoxic effect and the spread of antibiotic resistance within the compartments of the aquatic environment and wastewater treatment plants. Wastewater treatment plants are indeed the main source responsible for the prevalence of these factors in the aquatic environment, since predominantly the plants have not been designed to retain antimicrobial pharmaceuticals. In order to limit the prevalence of these impurities into the environment, better source control is recommended as well as the establishment of stricter environmental quality standards. Counteracting all the above-mentioned threats requires to undertake integrated activities based on cooperation of professionals and scientists from various fields of science or industry, such as environmental sciences, medicine, veterinary, pharmacology, chemical engineering and others.
- MeSH
- antiinfekční látky škodlivé účinky MeSH
- ekotoxikologie MeSH
- léková rezistence účinky léků MeSH
- lidé MeSH
- vodní organismy účinky léků MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Lab-scale membrane bioreactors (MBRs), with aerated activated sludge and internal microfiltration module, were used for the treatment of municipal wastewater containing high, yet environmentally relevant, concentrations of benzothiazole (BT) and benzotriazole (BTA). These high production volume compounds are commonly used in the industry and households, and therefore occur ubiquitously in municipal wastewater and the aquatic environment. The aim of this study was to assess the removal of BT and BTA from synthetic municipal wastewater in MBRs and to estimate the contribution of elimination processes and to identify potential biotransformation products. The overall removal of BT and BTA was high, and after the adaptation period, it reached 99.8% and 97.2%, respectively, but recurring periods of unstable BTA removal occurred. The removal due to biotransformation was 88% for BT and 84% for BTA and the disposal with waste sludge accounted for only <1% of the removed load. The remaining fraction of the removed load of BT and BTA was attributed to be retained by phenomena associated with membrane fouling. The adaptation process was reflected in multifold increase in biodegradation kinetic coefficient (kbiol) for BT (reported for the first time) and BTA. Biodegradation was attributed to catabolic mechanism rather than to cometabolism. Hydroxylation was observed to be the main transformation reaction for BT, whereas for BTA hydroxylation, methylation and cleavage of benzene ring were noted. This study has shown the feasibility of treating municipal wastewater with high concentrations of BT and BTA in MBRs and identified potential challenges for the removal of BTA.
The aim of this study was to evaluate the treatment of organic-carbon-deficient wastewater containing benzotriazole (BTA) in lab-scale aerated biofilters filled with natural manganese oxide ore, sand coated with synthetic manganese oxides and sand (as a control material) in terms of BTA removal efficiency, its transformation products and ecotoxicological impact of the treated wastewater. Additionally, the effect of Mn(II) feeding was tested. The removal of BTA in all the biofilters was ≥97%. The contribution of the biotic removal of this compound was 15%, 50%, and 75% in the systems filled with sand, synthetic and natural manganese oxides, respectively. Only the columns filled with natural manganese oxides provided significant removal of DOC and decrease of UV254 and SUVA254, with even more pronounced effect with Mn(II) feeding. The presence of Mn(II) was also found to enhance the removal of NNH4 in the systems filled with either form of manganese oxides, otherwise the removal of NNH4 was negligible or negative. The transformation reactions of BTA were methylation, hydroxylation, and triazole ring cleavage. Based on the number of compounds and their relative abundance, the methylated transformation products were predominant in the effluent. The reduction of the ecotoxicity (Microtox bioassay) of the effluents was positively correlated with the decrease of UV254, SUVA and DOC and only moderately with the removal of BTA. This study has shown that the natural manganese oxide ore provides the broadest set of services as a filtering material for aerated biofilters treating carbon-deficient wastewater containing BTA.
- MeSH
- čištění vody metody MeSH
- mangan chemie MeSH
- odpadní voda chemie MeSH
- oxidy MeSH
- sloučeniny manganu MeSH
- triazoly izolace a purifikace MeSH
- uhlík MeSH
- Publikační typ
- časopisecké články MeSH
