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Autor
Bajsova, Sylva 1 Barahona, Marc 1 Berjon, Alberto 1 Buda, Alessandro 1 Cibula, David 1 Dundr, Pavel 1 Fastrez, Maxime 1 Garcia, Francisco Javier de Santiago 1 Germanova, Anna 1 Gil-Ibanez, Blanca 1 Havelka, Pavel 1 Jarkovsky, Jiri 1 Kascak, Peter 1 Kipp, Barbara 1 Klat, Jaroslav 1 Kocian, Roman 1 Kohler, Christhardt 1 Lonkhuijzen, Luc van 1 Lupo, Ezequiel 1 Luyckx, Mathieu 1
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Pracoviště
Center for Gynecologic Oncology Acade... 1 Department of Gynaecology St Olav's H... 1 Department of Gynaecology and Obstetr... 1 Department of Gynaecology and Obstetr... 1 Department of Gynecologic Oncology Ce... 1 Department of Gynecologic Oncology Ho... 1 Department of Gynecology Francisco Ge... 1 Department of Gynecology Gynecologic ... 1 Department of Gynecology Medical Facu... 1 Department of Gynecology Universite c... 1 Department of Gynecology University H... 1 Department of Gynecology and Obstetri... 1 Department of Gynecology and Obstetri... 1 Department of Gynecology and Obstetri... 1 Department of Gynecology and Obstetri... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1
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Autor
Bajsova, Sylva 1 Barahona, Marc 1 Berjon, Alberto 1 Buda, Alessandro 1 Cibula, David 1 Dundr, Pavel 1 Fastrez, Maxime 1 Garcia, Francisco Javier de Santiago 1 Germanova, Anna 1 Gil-Ibanez, Blanca 1 Havelka, Pavel 1 Jarkovsky, Jiri 1 Kascak, Peter 1 Kipp, Barbara 1 Klat, Jaroslav 1 Kocian, Roman 1 Kohler, Christhardt 1 Lonkhuijzen, Luc van 1 Lupo, Ezequiel 1 Luyckx, Mathieu 1
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Pracoviště
Center for Gynecologic Oncology Acade... 1 Department of Gynaecology St Olav's H... 1 Department of Gynaecology and Obstetr... 1 Department of Gynaecology and Obstetr... 1 Department of Gynecologic Oncology Ce... 1 Department of Gynecologic Oncology Ho... 1 Department of Gynecology Francisco Ge... 1 Department of Gynecology Gynecologic ... 1 Department of Gynecology Medical Facu... 1 Department of Gynecology Universite c... 1 Department of Gynecology University H... 1 Department of Gynecology and Obstetri... 1 Department of Gynecology and Obstetri... 1 Department of Gynecology and Obstetri... 1 Department of Gynecology and Obstetri... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynaecol... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1 Department of Obstetrics and Gynecolo... 1
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Free Medical Journals od 2009
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PubMed
32365651
DOI
10.3390/cancers12051115
Knihovny.cz E-zdroje
The quality of pathological assessment is crucial for the safety of patients with cervical cancer if pelvic lymph node dissection is to be replaced by sentinel lymph node (SLN) biopsy. Central pathology review of SLN pathological ultrastaging was conducted in the prospective SENTIX/European Network of Gynaecological Oncological Trial (ENGOT)-CX2 study. All specimens from at least two patients per site were submitted for the central review. For cases with major or critical deviations, the sites were requested to submit all samples from all additional patients for second-round assessment. From the group of 300 patients, samples from 83 cases from 37 sites were reviewed in the first round. Minor, major, critical, and no deviations were identified in 28%, 19%, 14%, and 39% of cases, respectively. Samples from 26 patients were submitted for the second-round review, with only two major deviations found. In conclusion, a high rate of major or critical deviations was identified in the first round of the central pathology review (28% of samples). This reflects a substantial heterogeneity in current practice, despite trial protocol requirements. The importance of the central review conducted prospectively at the early phase of the trial is demonstrated by a substantial improvement of SLN ultrastaging quality in the second-round review.
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