Interleukin-1α (IL-1α) is a dual-function proinflammatory mediator. In addition to its role in the canonical IL-1 signaling pathway, which employs membrane-bound receptors, a growing body of evidence shows that IL-1α has some additional intracellular functions. We identified the interaction of IL-1α with the tumor suppressor p53 in the nuclei and cytoplasm of both malignant and noncancerous mammalian cell lines using immunoprecipitation and the in situ proximity ligation assay (PLA). This interaction was enhanced by treatment with the antineoplastic drug etoposide, which suggests a role for the IL-1α•p53 interaction in genotoxic stress.
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- cytoplazma metabolismus MeSH
- dvouřetězcové zlomy DNA MeSH
- fluorescenční mikroskopie MeSH
- HeLa buňky MeSH
- imunoprecipitace MeSH
- interleukin-1alfa genetika metabolismus MeSH
- lidé MeSH
- nádorový supresorový protein p53 genetika metabolismus MeSH
- poškození DNA genetika fyziologie MeSH
- western blotting MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- myši nahé MeSH
- myši MeSH
- nízká teplota MeSH
- syndromy imunologické nedostatečnosti MeSH
- termoregulace fyziologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- srovnávací studie MeSH