Evidence-based guidelines on the management of pain associated with first-trimester medical abortion are lacking. Most published clinical trials have failed to report on this important aspect of the procedure. The aim of this comprehensive work was to provide clinical advice based on a comprehensive literature review, supplemented by the clinical experience of a group of European experts in case no evidence is available. Pain level ranged from 5 to 8 in 80% of studies where pain was measured on a 0-10 visual analogue scale; severe pain was reported by 20-80% of women. Pain assessment was rarely reported in studies. Pain treatment should be preventive and avoidance of unnecessary uterine contractions should be considered. Analgesic treatment should follow the WHO three-step ladder, starting with the use of NSAIDs and allowing for easily available back-up treatment with weak opioids.

• MeSH
• abortiva steroidní škodlivé účinky   farmakologie   MeSH
• antiflogistika nesteroidní aplikace a dávkování   MeSH
• ibuprofen aplikace a dávkování   MeSH
• indukovaný potrat škodlivé účinky   metody   MeSH
• konsensus MeSH
• lidé MeSH
• management bolesti metody   MeSH
• měření bolesti metody   MeSH
• mifepriston škodlivé účinky   farmakologie   MeSH
• misoprostol škodlivé účinky   farmakologie   MeSH
• první trimestr těhotenství MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• systematický přehled MeSH