Siderophores play important roles in microbial iron piracy, and are applied as infectious disease biomarkers and novel pharmaceutical drugs. Inductively coupled plasma and molecular mass spectrometry (ICP-MS) combined with high resolution separations allow characterization of siderophores in complex samples taking advantages of mass defect data filtering, tandem mass spectrometry, and iron-containing compound quantitation. The enrichment approaches used in siderophore analysis and current ICP-MS technologies are reviewed. The recent tools for fast dereplication of secondary metabolites and their databases are reported. This review on siderophores is concluded with their recent medical, biochemical, geochemical, and agricultural applications in mass spectrometry context.
- MeSH
- antibiotická rezistence MeSH
- biodegradace MeSH
- chelátory farmakologie MeSH
- hmotnostní spektrometrie metody MeSH
- mikrobiální testy citlivosti MeSH
- sekundární metabolismus MeSH
- siderofory analýza chemie metabolismus farmakologie MeSH
- spektrofotometrie atomová metody MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
