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Autor
Alamri, Hassan 1 Cajka, Tomas 1 Demuth, Ilja 1 Fiehn, Oliver 1 Gupta, Nilaksh 1 Haghikia, Arash 1 Hazen, Stanley L 1 König, Maximilian 1 Landmesser, Ulf 1 Li, Xinmin S 1 Nemet, Ina 1 Nimer, Nisreen 1 Saha, Prasenjit Prasad 1 Steinhagen-Thiessen, Elisabeth 1 Tang, W H Wilson 1 Wilcox, Jennifer 1 Witkowski, Marco 1 Wu, Yuping 1
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Pracoviště
Berlin Institute of Health Berlin Ger... 1 Berlin Institute of Health Center for... 1 Department of Cardiology Angiology an... 1 Department of Cardiovascular and Meta... 1 Department of Clinical Laboratory Sci... 1 Department of Endocrinology and Metab... 1 Department of Mathematics and Statist... 1 Friede Springer Cardiovascular Preven... 1 German Center for Cardiovascular Rese... 1 Heart Vascular and Thoracic Institute... 1 Institute of Physiology of the Czech ... 1 West Coast Metabolomics Center Univer... 1
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Autor
Alamri, Hassan 1 Cajka, Tomas 1 Demuth, Ilja 1 Fiehn, Oliver 1 Gupta, Nilaksh 1 Haghikia, Arash 1 Hazen, Stanley L 1 König, Maximilian 1 Landmesser, Ulf 1 Li, Xinmin S 1 Nemet, Ina 1 Nimer, Nisreen 1 Saha, Prasenjit Prasad 1 Steinhagen-Thiessen, Elisabeth 1 Tang, W H Wilson 1 Wilcox, Jennifer 1 Witkowski, Marco 1 Wu, Yuping 1
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Pracoviště
Berlin Institute of Health Berlin Ger... 1 Berlin Institute of Health Center for... 1 Department of Cardiology Angiology an... 1 Department of Cardiovascular and Meta... 1 Department of Clinical Laboratory Sci... 1 Department of Endocrinology and Metab... 1 Department of Mathematics and Statist... 1 Friede Springer Cardiovascular Preven... 1 German Center for Cardiovascular Rese... 1 Heart Vascular and Thoracic Institute... 1 Institute of Physiology of the Czech ... 1 West Coast Metabolomics Center Univer... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
- Vlastník
- Witkowski, Marco
- Nemet, Ina
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Alamri, Hassan
Autor Alamri, Hassan ORCID Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
- Wilcox, Jennifer
- Gupta, Nilaksh
- Nimer, Nisreen
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Haghikia, Arash
Autor Haghikia, Arash ORCID Department of Cardiology, Angiology and Intensive Care, German Heart Center of Charité, Campus Benjamin Franklin, Berlin, Germany German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany Berlin Institute of Health (BIH), Berlin, Germany Friede Springer Cardiovascular Prevention Center at Charité, Berlin, Germany
- Li, Xinmin S
- Wu, Yuping
- Saha, Prasenjit Prasad
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
PubMed
36849732
DOI
10.1038/s41591-023-02223-9
Knihovny.cz E-zdroje
Artificial sweeteners are widely used sugar substitutes, but little is known about their long-term effects on cardiometabolic disease risks. Here we examined the commonly used sugar substitute erythritol and atherothrombotic disease risk. In initial untargeted metabolomics studies in patients undergoing cardiac risk assessment (n = 1,157; discovery cohort, NCT00590200 ), circulating levels of multiple polyol sweeteners, especially erythritol, were associated with incident (3 year) risk for major adverse cardiovascular events (MACE; includes death or nonfatal myocardial infarction or stroke). Subsequent targeted metabolomics analyses in independent US (n = 2,149, NCT00590200 ) and European (n = 833, DRKS00020915 ) validation cohorts of stable patients undergoing elective cardiac evaluation confirmed this association (fourth versus first quartile adjusted hazard ratio (95% confidence interval), 1.80 (1.18-2.77) and 2.21 (1.20-4.07), respectively). At physiological levels, erythritol enhanced platelet reactivity in vitro and thrombosis formation in vivo. Finally, in a prospective pilot intervention study ( NCT04731363 ), erythritol ingestion in healthy volunteers (n = 8) induced marked and sustained (>2 d) increases in plasma erythritol levels well above thresholds associated with heightened platelet reactivity and thrombosis potential in in vitro and in vivo studies. Our findings reveal that erythritol is both associated with incident MACE risk and fosters enhanced thrombosis. Studies assessing the long-term safety of erythritol are warranted.
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