It is generally known that prevalence of allergic diseases in developed countries is increasing. Same trend we registered in the most serious allergic reaction, which is called anaphylaxis. So far there has not been not enough proof of anaphylaxis in children in the Czech Republic. The goal of our study is to bring the data about occurrence of anaphylaxis in Kolín and Pardubice district, triggers and treatment of anaphylaxis. In our study we enrolled 52 paediatric patients, who suffered from anaphylaxis between June 2014 and June 2019 and they were hospitalized or examined in the paediatric department in hospitals in Pardubice and Kolín. The most common trigger of anaphylaxis was food (29 cases), predominantly peanuts that caused 10 anaphylactic reactions in our cohort. With increasing patient’sage we observed more reactions caused by insect stings. That was the second most common trigger in our study (18 cases). Majority of our patients was treated by antihistamines (83% of patients) and corticosteroids (76% of patients). Epinephrine was used in 24% of patients, predominantly route of application was intrasmuscular. No fatal reaction was observed
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