The hippocampus plays a crucial role in the formation and retrieval of spatial memory across mammals and episodic memory in humans. Episodic and spatial memories can be retrieved irrespective of the subject's awake behavioral state and independently of its actual spatial context. However, the nature of hippocampal network activity during such out-context retrieval has not been described so far. Theoretically, context-independent spatial memory retrieval suggests a shift of the hippocampal spatial representations from coding the current spatial context to coding the remembered environment. In this study we show in rats that the CA3 neuronal population can switch spontaneously across representations and transiently activate another stored familiar spatial pattern without direct external sensory cuing. This phenomenon qualitatively differs from the well-described sharp wave-related pattern reactivations during immobility. Here, it occurs under the theta oscillatory state during active exploration and reflects the preceding experience of sudden environmental change. The respective out-context coding spikes appeared later in the theta cycle than the in-context ones. Finally, the experience also induced the emergence of population vectors with a co-expression of both codes segregated into different phases of the theta cycle.

• MeSH
• epizodická paměť * MeSH
• hipokampus MeSH
• krysa rodu rattus MeSH
• lidé MeSH
• plži * MeSH
• podněty MeSH
• prostorová paměť MeSH
• rozpomínání MeSH
• savci MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

• MeSH
• elektroencefalografie MeSH
• hipokampus fyziologie   patofyziologie   účinky léků   MeSH
• modely u zvířat MeSH
• nervová síť MeSH
• paměť * fyziologie   účinky léků   MeSH
• potkani Long-Evans MeSH
• pyramidové buňky fyziologie   patologie   MeSH
• receptory N-methyl-D-aspartátu antagonisté a inhibitory   aplikace a dávkování   MeSH
• rozpomínání fyziologie   účinky léků   MeSH
• Publikační typ
• práce podpořená grantem MeSH