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Autor
Krebs, Kristi 2 Milani, Lili 2 Abramova, Liliya 1 Adolfsson, Rolf 1 Adorjan, Kristina 1 Agartz, Ingrid 1 Agerbo, Esben 1 Al Eissa, Mariam 1 Albani, Diego 1 Alda, Martin 1 Alfredsson, Lars 1 Alliey-Rodriguez, Ney 1 Als, Thomas D 1 Andreassen, Ole A 1 Anjorin, Adebayo 1 Antilla, Verneri 1 Antoniou, Anastasia 1 Awasthi, Swapnil 1 Babadjanova, Gulja 1 Backlund, Lena 1
- Organizace
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Pracoviště
1st Department of Psychiatry Eginitio... 1 2nd Department of Psychiatry Attikon ... 1 APHP Nord DMU Neurosciences Départeme... 1 Academic Psychiatry Newcastle Univers... 1 Analytic and Translational Genetics U... 1 Biochemistry and Molecular Biology In... 1 Bioinformatics Research Centre Aarhus... 1 Biomedical Research Center University... 1 Biometric Psychiatric Genetics Resear... 1 Campbell Family Mental Health Researc... 1 Cancer Epidemiology and Prevention M ... 1 Cell Biology SUNY Downstate Medical C... 1 Center for Genomics and Personalized ... 1 Center for GeoGenetics GLOBE Institut... 1 Center for Molecular Medicine Karolin... 1 Center for Multimodal Imaging and Gen... 1 Center for Neonatal Screening Departm... 1 Center for Neurobehavioral Genetics S... 1 Center for Statistical Genetics and D... 1 Center for Studies of Addiction Unive... 1
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Autor
Krebs, Kristi 2 Milani, Lili 2 Abramova, Liliya 1 Adolfsson, Rolf 1 Adorjan, Kristina 1 Agartz, Ingrid 1 Agerbo, Esben 1 Al Eissa, Mariam 1 Albani, Diego 1 Alda, Martin 1 Alfredsson, Lars 1 Alliey-Rodriguez, Ney 1 Als, Thomas D 1 Andreassen, Ole A 1 Anjorin, Adebayo 1 Antilla, Verneri 1 Antoniou, Anastasia 1 Awasthi, Swapnil 1 Babadjanova, Gulja 1 Backlund, Lena 1
- Organizace
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Pracoviště
1st Department of Psychiatry Eginitio... 1 2nd Department of Psychiatry Attikon ... 1 APHP Nord DMU Neurosciences Départeme... 1 Academic Psychiatry Newcastle Univers... 1 Analytic and Translational Genetics U... 1 Biochemistry and Molecular Biology In... 1 Bioinformatics Research Centre Aarhus... 1 Biomedical Research Center University... 1 Biometric Psychiatric Genetics Resear... 1 Campbell Family Mental Health Researc... 1 Cancer Epidemiology and Prevention M ... 1 Cell Biology SUNY Downstate Medical C... 1 Center for Genomics and Personalized ... 1 Center for GeoGenetics GLOBE Institut... 1 Center for Molecular Medicine Karolin... 1 Center for Multimodal Imaging and Gen... 1 Center for Neonatal Screening Departm... 1 Center for Neurobehavioral Genetics S... 1 Center for Statistical Genetics and D... 1 Center for Studies of Addiction Unive... 1
- Formát
- Publikační typ
- Check Tag
- Kategorie
- Jazyk
- Země
- Časopis/zdroj
- Dostupnost
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Digitální knihovna NLK
Zdroj
E-zdroje NLK Online
ROAD: Directory of Open Access Scholarly Resources od 2011- Publikační typ
- abstrakt z konference MeSH
- Mullins, Niamh
- Forstner, Andreas J
- O'Connell, Kevin S
- Coombes, Brandon
- Coleman, Jonathan R I
- Qiao, Zhen
- Als, Thomas D
- Bigdeli, Tim B
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Børte, Sigrid
Autor Børte, Sigrid Research and Communication Unit for Musculoskeletal Health, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway K. G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
- Bryois, Julien
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 2000-01-01 do Před 1 rokem
PubMed
34002096
DOI
10.1038/s41588-021-00857-4
Knihovny.cz E-zdroje
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies.
- MeSH
- bipolární porucha genetika MeSH
- celogenomová asociační studie * MeSH
- fenotyp MeSH
- genetická predispozice k nemoci MeSH
- genom lidský MeSH
- hlavní histokompatibilní komplex genetika MeSH
- lidé MeSH
- lidské chromozomy genetika MeSH
- lokus kvantitativního znaku genetika MeSH
- multifaktoriální dědičnost genetika MeSH
- rizikové faktory MeSH
- studie případů a kontrol MeSH
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- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- Research Support, N.I.H., Extramural MeSH
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