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3rd Faculty of Medicine Charles Unive... 1 Centre for Public Health Promotion Na... 1 Department of Internal Medicine Králo... 1 Division of Cancer Epidemiology Germa... 1 Faculty of Medicine University of Zur... 1 Faculty of Medicine and University Ho... 1 German Center for Diabetes Research P... 1 Institute for Biometrics and Epidemio... 1 Institute for Evidence in Medicine Me... 1 Institute for Global Food Security Qu... 1
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3rd Faculty of Medicine Charles Unive... 1 Centre for Public Health Promotion Na... 1 Department of Internal Medicine Králo... 1 Division of Cancer Epidemiology Germa... 1 Faculty of Medicine University of Zur... 1 Faculty of Medicine and University Ho... 1 German Center for Diabetes Research P... 1 Institute for Biometrics and Epidemio... 1 Institute for Evidence in Medicine Me... 1 Institute for Global Food Security Qu... 1
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- Selinger, Eliška
- Neuenschwander, Manuela
- Koller, Alina
- Gojda, Jan
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Kühn, Tilman
Autor Kühn, Tilman ORCID Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany Faculty of Medicine and University Hospital, Heidelberg Institute of Global Health (HIGH), Heidelberg, Germany Institute for Global Food Security (IGFS), Queen's University, Belfast, UK
- Schwingshackl, Lukas
- Barbaresko, Janett
- Schlesinger, Sabrina
To summarize and evaluate the evidence on the health impact of a vegan diet, we conducted an umbrella review of systematic reviews and meta-analyses. PubMed, Cochrane Library, Web of Science and Epistemonikos were searched up to September 2021. Meta-analyses were recalculated by using a random effects model. The certainty of evidence (CoE) was evaluated by the GRADE approach. For the general healthy population, a vegan diet was effective for reducing body weight [MD (95% CI): -2.52 kg (-3.06, -1.98), n = 8 RCTs; moderate CoE] and was associated with further health benefits (with low CoE), including a lower risk of cancer incidence [SRR (95% CI): 0.84 (0.75, 0.95), n = 2] and a trend for lower risk of all-cause mortality [SRR (95% CI): 0.87 (0.75, 1.01), n = 2], as well as lower ApoB levels [MD (95% CI): -0.19 μmol/L (-0.23, -0.15), n = 7 RCTs). The findings suggested adverse associations for a vegan diet with risk of fractures [SRR (95% CI): 1.46 (1.03, 2.07), n = 3; low CoE]. For persons with diabetes or at high CVD risk, a vegan diet reduced measures of adiposity, total cholesterol, LDL and improved glycemic control (CoE moderate to low). A vegan diet may have the potential for the prevention of cardiometabolic health, but it may also impair bone health. More well-conducted primary studies are warranted.
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- dieta veganská * MeSH
- hodnocení rizik MeSH
- lidé MeSH
- nádory * prevence a kontrola MeSH
- systematický přehled jako téma MeSH
- tělesná hmotnost MeSH
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