We describe a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma (PTC-FLS) that contained the rare BRAF c.1799_1801delTGA (p.V600_K601delinsE) mutation, which has not previously been reported in this tumour, as well as the CTNNB1 c.133T>C (p.S45P) mutation. We also report the novel observation that spindle cells of the mesenchymal component exhibit diffuse nuclear but not cytoplasmic expression of SOX11, whereas the malignant epithelial cells did not. This suggests that immunoreactivity for SOX11 can be an alternative diagnostic tool for evaluating cases of PTC-FLS where the nuclear expression of β-catenin is ambiguous.
- MeSH
- beta-katenin genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- mutace MeSH
- nádory štítné žlázy genetika metabolismus patologie MeSH
- papilární karcinom štítné žlázy genetika metabolismus patologie MeSH
- protoonkogenní proteiny B-raf genetika MeSH
- transkripční faktory SOXC biosyntéza MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
