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Autor
Aktas, Orhan 1 Auer, Michael 1 Bachelet, Delphine 1 Bertotti, Elisa 1 Broët, Philippe 1 Buck, Dorothea 1 Comabella, Manuel 1 Deisenhammer, Florian 1 Derfuss, Tobias 1 Donnellan, Naoimh 1 Dönnes, Pierre 1 Fernandez-Rodriguez, Blanca M 1 Fissolo, Nicolas 1 Fogdell-Hahn, Anna 1 Gasis, Marcia 1 Grummel, Verena 1 Guger, Michael 1 Hartung, Hans-Peter 1 Havrdova, Eva Kubala 1 Hemmer, Bernhard 1
- Organizace
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Pracoviště
Assistance Publique Hôpitaux de Paris... 1 CESP INSERM UMR 1018 Faculty of Medic... 1 Clinic for Neurology 2 Kepler Univers... 1 Danish Multiple Sclerosis Center Depa... 1 Department of Clinical Neuroscience K... 1 Department of Neurology Medical Unive... 1 Department of Neurology Technische Un... 1 Department of Neurology University Ho... 1 Departments of Biomedicine and Neurol... 1 Drug Metabolism Pharmacokinetics Biol... 1 GlaxoSmithKline R and D Uxbridge Midd... 1 Hospital Regional Universitario de Má... 1 Hospital Universitari Vall d'Hebron C... 1 INSERM UMR 996 Univ Paris Sud Faculty... 1 Innsbruck Medical University Innsbruc... 1 Ipsen Biopharm Ltd Berkshire United K... 1 KTH Royal Institute of Technology Sto... 1 MS Center Department of Neurology and... 1 Merck NBE Bioanalytics Ivrea Colleret... 1 Munich Cluster for systems Neurology ... 1
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Autor
Aktas, Orhan 1 Auer, Michael 1 Bachelet, Delphine 1 Bertotti, Elisa 1 Broët, Philippe 1 Buck, Dorothea 1 Comabella, Manuel 1 Deisenhammer, Florian 1 Derfuss, Tobias 1 Donnellan, Naoimh 1 Dönnes, Pierre 1 Fernandez-Rodriguez, Blanca M 1 Fissolo, Nicolas 1 Fogdell-Hahn, Anna 1 Gasis, Marcia 1 Grummel, Verena 1 Guger, Michael 1 Hartung, Hans-Peter 1 Havrdova, Eva Kubala 1 Hemmer, Bernhard 1
- Organizace
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Pracoviště
Assistance Publique Hôpitaux de Paris... 1 CESP INSERM UMR 1018 Faculty of Medic... 1 Clinic for Neurology 2 Kepler Univers... 1 Danish Multiple Sclerosis Center Depa... 1 Department of Clinical Neuroscience K... 1 Department of Neurology Medical Unive... 1 Department of Neurology Technische Un... 1 Department of Neurology University Ho... 1 Departments of Biomedicine and Neurol... 1 Drug Metabolism Pharmacokinetics Biol... 1 GlaxoSmithKline R and D Uxbridge Midd... 1 Hospital Regional Universitario de Má... 1 Hospital Universitari Vall d'Hebron C... 1 INSERM UMR 996 Univ Paris Sud Faculty... 1 Innsbruck Medical University Innsbruc... 1 Ipsen Biopharm Ltd Berkshire United K... 1 KTH Royal Institute of Technology Sto... 1 MS Center Department of Neurology and... 1 Merck NBE Bioanalytics Ivrea Colleret... 1 Munich Cluster for systems Neurology ... 1
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Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-β) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-β-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-β ADA in patients' sera. For clinical samples, selection of method of ELISA should be evaluated prior to the use of a multi-tiered approach. A titer threshold value is reported that may be used as a predictor for persistently positive neutralizing ADA.
- MeSH
- biotest MeSH
- ELISA MeSH
- imunologické faktory imunologie terapeutické užití MeSH
- interferon beta imunologie terapeutické užití MeSH
- lidé MeSH
- neutralizační testy metody MeSH
- neutralizující protilátky krev MeSH
- roztroušená skleróza krev farmakoterapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
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