Secondary prevention of peripheral arterial disease (PAD) includes administration of antiplatelet agents, and adherence to medication is a requirement for an effective treatment. The aim of this study was to analyse adherence measured using the proportion of days covered (PDC) index separately in persistent and non-persistent patients, and to identify patient- and medication-related characteristics associated with non-adherence in these patient groups. The study cohort of 9178 patients aged ≥ 65 years in whom PAD was diagnosed in 1/-12/2012 included 6146 persistent and 3032 non-persistent patients. Non-adherence was identified as PDC < 80%. Characteristics associated with non-adherence were determined using the binary logistic regression model. In the group of persistent patients, 15.3% of subjects were identified as non-adherent, while among non-persistent patients, 26.9% of subjects were non-adherent to antiplatelet medication. Administration of dual antiplatelet therapy (aspirin and clopidogrel) and a general practitioner as index prescriber were associated with adherence in both patient groups. Our study revealed a relatively high proportion of adherent patients not only in the group of persistent patients but also in the group of non-persistent patients before discontinuation. These results indicate that most non-persistent PAD patients discontinue antiplatelet treatment rapidly after a certain period of adherence.
- Publikační typ
- časopisecké články MeSH
The effectiveness of statins in secondary prevention of peripheral arterial disease (PAD) largely depends on patients' adherence to treatment. The aims of our study were: (a) to analyze non-adherence during the whole follow-up in persistent patients, and only during persistence for non-persistent patients; (b) to identify factors associated with non-adherence separately among persistent and non-persistent patients. A cohort of 8330 statin users aged ≥65 years, in whom PAD was newly diagnosed between January 2012-December 2012, included 5353 patients persistent with statin treatment, and 2977 subjects who became non-persistent during the 5-year follow-up. Non-adherence was defined using the proportion of days covered <80%. Patient- and statin-related characteristics associated with non-adherence were identified with binary logistic regression. A significantly higher proportion of non-adherent patients was found among non-persistent patients compared to persistent subjects (43.6% vs. 29.6%; p < 0.001). Associated with non-adherence in both persistent and non-persistent patients was high intensity statin treatment, while in non-persistent patients, it was employment and increasing number of medications. In patients with a poor adherence during their persistent period, an increased risk for discontinuation may be expected. However, there is also non-adherence among persistent patients. There are differences in factors associated with non-adherence depending on patients' persistence.
- Publikační typ
- časopisecké články MeSH
Group mean isopotential maps of initial parts of ventricular depolarization (QRS complex) in 4 age groups (10, 14, 19 and 22 years) of young healthy subjects, females and males, were analyzed using different increments between isopotential lines. It was found that the increment 0.1 mV masks some features of the maps, which are seen only by smaller increment (0.02 mV): the time of appearance of maximum and minimum on the anterior chest, smaller voltage values of the extrema as usually published, minimum dominating over maximum in the youngest groups. Therefore, the often applied criterion for the QRS onset - the increasing maximum on the anterior chest - should be reconsidered at least when it concerns the isopotential maps of children.
- MeSH
- dítě MeSH
- elektrokardiografie * MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- převodní systém srdeční fyziologie MeSH
- srdce - funkce komor * MeSH
- zdraví dobrovolníci pro lékařské studie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
Vydanie prvé 224 stran : ilustrace, tabulky ; 24 cm
Publikácia sa zameriava na metódy štatistického spracovania dát z medicínskeho výskumu a na prezentáciu výsledkov. Určené odbornej verejnosti.
- MeSH
- biomedicínský výzkum MeSH
- lékařská informatika MeSH
- statistika jako téma MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Lékařské vědy. Lékařství
- NLK Obory
- statistika, zdravotnická statistika
