Per(2,3,6-tri-O-benzyl)-γ-cyclodextrin was debenzylated by DIBAL-H to produce a mixture of C6(I),C6(IV) and C6(I),C6(V) isomeric diols, which were separated and isolated. The C2-symmetrical C6(I),C6(V) diol was transformed into dithiol and dimerized to produce a γ-cyclodextrin duplex structure. A crystal structure revealed tubular cavity whose peripheries are slightly elliptically distorted. The solvent accessible volume of the cavity of the γ-CD duplex is about 740 Å(3). Due to this large inner space the duplex forms very stable inclusion complexes with steroids; bile acids examined in this study show binding affinities to the γ-cyclodextrin duplex in the range of 5.3 × 10(7) M(-1)-1.9 × 10(8) M(-1).

• MeSH
• dimerizace MeSH
• disulfidy chemie   MeSH
• farmaceutická chemie metody   MeSH
• gama-cyklodextriny chemická syntéza   chemie   MeSH
• imatinib mesylát chemie   MeSH
• kalorimetrie MeSH
• kinetika MeSH
• koncentrace vodíkových iontů MeSH
• krystalografie rentgenová MeSH
• kyselina lithocholová chemie   MeSH
• kyslík chemie   MeSH
• magnetická rezonanční spektroskopie MeSH
• molekulární konformace MeSH
• rozpouštědla chemie   MeSH
• steroidy chemie   MeSH
• sulfhydrylové sloučeniny chemie   MeSH
• termodynamika MeSH
• vazba proteinů MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH