This study investigated the effect of hormonal changes on semen quality, chromatin status, and assisted reproductive outcomes (intracytoplasmic sperm injection), among infertile men. In this research, 219 infertile men undergoing assisted reproductive treatment were evaluated with reproductive hormone levels (including follicle-stimulating hormone, luteinizing hormone and testosterone), semen parameters, and sperm chromatin integrity and condensation, between 2012 and 2014. Finally, the assisted reproductive outcomes in these infertile men were studied. The low rate of total sperm count, motility and morphology, fertilization and the high percentage of DNA damage, the poor zygote (Z4 grade) and embryo quality (grade D), and spontaneous miscarriage was recorded in men with high levels of follicle-stimulating hormone and luteinizing hormone. In conclusion, the changes in the follicle-stimulating hormone, luteinizing hormone, and testosterone by changes in the sperm quality, and DNA damage may have the effects on assisted reproductive outcomes (e.g., low fertilization, poor zygote and embryo quality, and high miscarriage).
- MeSH
- asistovaná reprodukce * MeSH
- chromatin genetika MeSH
- dospělí MeSH
- folikuly stimulující hormon krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- luteinizační hormon krev MeSH
- mladý dospělý MeSH
- motilita spermií MeSH
- mužská infertilita * krev terapie MeSH
- počet spermií MeSH
- poškození DNA MeSH
- samovolný potrat MeSH
- těhotenství statistika a číselné údaje MeSH
- testosteron krev MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- těhotenství statistika a číselné údaje MeSH
- ženské pohlaví MeSH
