International journal of clinical pharmacology and therapeutics.
2001 ;
Roč. 39 (č. 4) :
s. 179-184.
Československá dermatologie.
1997 ;
Roč. 72 (č. 6) :
s. 230-234.
The in vitro steady state fluxes (8-48h) of acyclovir were measured using full-thickness excised human skin to compare the transdermal permeation of the drug from two commercial topical preparations Herpesin cream and Zovirax cream. The variable, BR (bioavailability ratio), characterizing the mean ratio of the transdermal fluxes of acyclovir from Herpesin cream to the fluxes fi-om Zovirax cream, was BR = 1,1 ± 0,16, and confirms the topical bioequivalence ofthe preparations tested.
