A novel derivative of 6-methyluracil, C-547, increased the amplitude and prolonged the duration of miniature endplate currents (MEPCs) which is typical for acetylcholinesterase inhibition. In the soleus and extensor digitorum longus significant potentiation was detected at nanomolar concentrations. In contrast, in the diaphragm muscle, the increase in the amplitudes of the MEPCs and the decay time constant ? appeared only when the concentration of C-547 was elevated to 1x10-7 M. Possible consequences for the exploitation of this drug, which can selectively inhibit AChE in particular synapses, are discussed.

• MeSH
• acetylcholinesterasa farmakokinetika   účinky léků   MeSH
• bránice fyziologie   účinky léků   MeSH
• cholinesterasové inhibitory farmakokinetika   chemie   MeSH
• elektrofyziologie metody   statistika a číselné údaje   MeSH
• financování vládou MeSH
• interpretace statistických dat MeSH
• nervosvalová ploténka enzymologie   fyziologie   chemie   MeSH
• potkani Wistar fyziologie   MeSH
• svaly fyziologie   účinky léků   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• srovnávací studie MeSH