BACKGROUND AND AIM: Melibiose/rhamnose permeability test is used for noninvasive intestinal mucosa barrier testing. However, the possible escape route of the absorbed saccharides through either intact or impaired blood-biliary barriers has not so far been explored. The objective of the present study was therefore two-fold: First, to describe in detail the biliary pharmacokinetics of melibiose and rhamnose in rats; second, to evaluate the changes of both sugars' pharmacokinetics upon impairment of the blood-biliary barrier by acute extrahepatic cholestasis in rats.

• MeSH
• Acute Disease MeSH
• Cholestasis diagnosis   metabolism   MeSH
• Diagnostic Techniques, Digestive System MeSH
• Financing, Organized MeSH
• Injections, Intravenous MeSH
• Rats MeSH
• Melibiose administration & dosage   diagnostic use   pharmacokinetics   urine   MeSH
• Disease Models, Animal MeSH
• Permeability MeSH
• Rats, Wistar MeSH
• Rhamnose administration & dosage   diagnostic use   pharmacokinetics   urine   MeSH
• Tight Junctions metabolism   MeSH
• Up-Regulation MeSH
• Chromatography, High Pressure Liquid MeSH
• Bile metabolism   MeSH
• Bile Canaliculi metabolism   MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Male MeSH
• Animals MeSH