In 2019, a novel virus emerged in Wuhan, China that caused a febrile respiratory illness, sometimes rapidly fatal and thought to be transmitted by droplet contact. It likely originated from another species (possibly the bat), but later, spread occurred from human-to-human. Over a period of months, this disease disseminated to more than 100 nations as a highly infectious pandemic, reminiscent of disease associated with other coronavirus agents in 2002 (SARS) and 2012 (MERS). This COVID-19 virus also caused other forms of clinical illness, albeit in the minority, and most infected patients (over 50%) had few symptoms or remained completely asymptomatic. Prominent in some patients was watery diarrhea, often lasting less than a week, but sometimes without any respiratory features, such as fever, cough or shortness of breath. It is believed that fecal-oral transmission may result. The virus attaches to the surface of human respiratory and intestinal cells, gains entry into these cells, ultimately leading to production of new virions intraluminally. Fecal shedding may occur for extended periods, even after respiratory secretions become negative. Apart from preventive measures, vaccine development remains the most important strategy.

• Klíčová slova
• Covid 19,
• MeSH
• angiotensin konvertující enzym 2 škodlivé účinky   MeSH
• COVID-19 * patofyziologie   patologie   MeSH
• feces virologie   MeSH
• internalizace viru MeSH
• lidé MeSH
• průjem * etiologie   patofyziologie   MeSH
• receptory koronavirů MeSH
• SARS-CoV-2 enzymologie   patogenita   MeSH
• střevní sliznice patologie   virologie   MeSH
• vylučování virů MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• přehledy MeSH

The severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) dwells in the respiratory airways, however, its digestive tract presence, infectivity, mucosal attachment and penetrating mechanisms, enteric proliferation, stool shading, flashed bio-aerosol spreading and fecal-oral transmission is far from being understood. The present review opens some skylights to lighten the long, tortuous, dark and challenging tunnel of the gastrointestinal tract and his uninvited covid-19 viral new inhabitant.

• Klíčová slova
• Covid 19,
• MeSH
• angiotensin konvertující enzym 2 škodlivé účinky   MeSH
• COVID-19 * etiologie   mortalita   patofyziologie   patologie   přenos   MeSH
• endoskopie škodlivé účinky   MeSH
• feces virologie   MeSH
• gastrointestinální trakt patofyziologie   patologie   virologie   MeSH
• lidé MeSH
• průjem etiologie   MeSH
• receptory koronavirů MeSH
• SARS-CoV-2 patogenita   MeSH
• střeva * virologie   MeSH
• virom MeSH
• vylučování virů MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• přehledy MeSH