The authors report 10 cases of lymphoepithelioma-like carcinoma (LELC) of the skin and the results of a molecular biological study for HPV, EBV, and SV40 in lesional tissues. All patients originated from Central Europe. There were seven men and three women, ranging in age from 57 to 86 years. Locations included the face (n = 4), scalp (n = 2), penis (n = 2), and retroauricular area (n = 1); location was unknown for one subject. All but two patients presented with a tumor confined to the skin; in both patients with the penile carcinoma, the tumors had metastasized to an inguinal lymph node. Six patients with available follow-up included four individuals with no evidence of tumor metastasis or recurrences at 2, 3, 4, and 5 years, one patient who died with metastatic disease 7 years after diagnosis, and one patient who died of an unrelated course. Microscopically, all cases showed distinctive features of LELC characterized by variably sized and shaped nodules or syncytial sheets of epithelial cells that contained vesicular chromatic and prominent nucleoli and that were permeated and surrounded by small, well-differentiated lymphocytes and plasma cells. Because all 10 cases studied proved negative for EBV, HPV, and SV40, these viruses seem to play no causal role in LELC of the skin in patients from Central Europe.

• MeSH
• Alphapapillomavirus izolace a purifikace   MeSH
• buněčné jadérko ultrastruktura   MeSH
• epitelové buňky patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lymfatické metastázy patologie   MeSH
• lymfocyty patologie   MeSH
• míra přežití MeSH
• nádory kůže virologie   MeSH
• nádory obličeje virologie   MeSH
• nádory penisu virologie   MeSH
• nádory ucha virologie   MeSH
• následné studie MeSH
• opičí virus SV40 izolace a purifikace   MeSH
• plazmatické buňky patologie   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• skalp virologie   MeSH
• spinocelulární karcinom sekundární   virologie   MeSH
• virus Epsteinův-Barrové izolace a purifikace   MeSH
• zevní ucho virologie   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Geografické názvy
• Česká republika MeSH
• Slovenská republika MeSH