BACKGROUND: Preterm birth is a leading cause of perinatal mortality and morbidity. Heavy cervicovaginal Ureaplasma colonization is thought to play a role in the pathogenesis of preterm birth. The administration of vaginal progesterone has been shown to reduce the incidence of preterm birth in women with short cervical length. Steroid hormones seem to modulate the presence of microorganisms in the vagina. The aim of this study was to assess whether the treatment with vaginal progesterone could reduce the incidence of preterm birth and cervicovaginal colonization by Ureaplasma urealyticum in a cohort of pregnant women with threatened preterm labor. METHODS: A cohort of 63 females who presented with regular contractions and/or short cervical length between 24-32 weeks of gestation were recruited into a prospective study. 70% of patients had been treated with vaginal progesterone prior to recruitment and these patients continued with the treatment until birth. All patients were tested for the presence of cervicovaginal Ureaplasma urealyticum colonization at admission. The primary endpoint was preterm birth before 37 weeks. RESULTS: The incidence of preterm delivery was significantly increased in patients who tested positive for Ureaplasma urealyticum. Prolonged vaginal progesterone administration was associated with less frequent cervicovaginal colonization by U. urealyticum. Cervicovaginal colonization by U. urealyticum and absence of progesterone treatment were identified as two independent risk factors for preterm delivery. CONCLUSIONS: Our results demonstrate the beneficial effects of progesterone administration in reducing the incidence of cervicovaginal colonization by Ureaplasma urealyticum.
- MeSH
- antiinfekční látky terapeutické užití MeSH
- aplikace intravaginální MeSH
- cervix uteri mikrobiologie MeSH
- dospělí MeSH
- kohortové studie MeSH
- lidé MeSH
- předčasný porod epidemiologie terapie MeSH
- progesteron terapeutické užití MeSH
- prospektivní studie MeSH
- rizikové faktory MeSH
- těhotenství MeSH
- Ureaplasma urealyticum imunologie MeSH
- ureaplasmatické infekce epidemiologie terapie MeSH
- vagina mikrobiologie MeSH
- výsledek těhotenství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- MeSH
- chlamydiové infekce diagnóza epidemiologie terapie MeSH
- lidé MeSH
- mladiství MeSH
- mužské urogenitální nemoci MeSH
- mykoplazmové infekce diagnóza epidemiologie terapie MeSH
- ureaplasmatické infekce diagnóza epidemiologie terapie MeSH
- ženské urogenitální nemoci a komplikace těhotenství etiologie MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
- MeSH
- bakteriální vaginóza mikrobiologie MeSH
- chlamydiové infekce epidemiologie MeSH
- lidé MeSH
- mykoplazmové infekce epidemiologie MeSH
- nemoci cervix uteri mikrobiologie MeSH
- sexuálně přenosné nemoci bakteriální MeSH
- ureaplasmatické infekce epidemiologie MeSH
- ženská infertilita mikrobiologie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
