Vector-borne diseases cause over 700,000 deaths annually and represent 17% of all infectious illnesses worldwide. This public health menace highlights the importance of understanding how arthropod vectors, microbes and their mammalian hosts interact. Currently, an emphasis of the scientific enterprise is at the vector-host interface where human pathogens are acquired and transmitted. At this spatial junction, arthropod effector molecules are secreted, enabling microbial pathogenesis and disease. Extracellular vesicles manipulate signaling networks by carrying proteins, lipids, carbohydrates and regulatory nucleic acids. Therefore, they are well positioned to aid in cell-to-cell communication and mediate molecular interactions. This Review briefly discusses exosome and microvesicle biogenesis, their cargo, and the role that nanovesicles play during pathogen spread, host colonization and disease pathogenesis. We then focus on the role of extracellular vesicles in dictating microbial pathogenesis and host immunity during transmission of vector-borne pathogens.
- MeSH
- amébiáza parazitologie přenos MeSH
- členovci - vektory * mikrobiologie parazitologie MeSH
- Culicidae mikrobiologie parazitologie MeSH
- exozómy imunologie mikrobiologie parazitologie MeSH
- extracelulární vezikuly * imunologie mikrobiologie parazitologie MeSH
- filarióza parazitologie přenos MeSH
- Hemiptera mikrobiologie parazitologie MeSH
- imunomodulace MeSH
- infekce přenášené vektorem MeSH
- interakce hostitele a parazita imunologie fyziologie MeSH
- leishmanióza parazitologie přenos MeSH
- lidé MeSH
- malárie parazitologie přenos MeSH
- nemoci přenášené vektory * mikrobiologie parazitologie přenos MeSH
- Psychodidae mikrobiologie parazitologie MeSH
- trypanozomiáza parazitologie přenos MeSH
- virové nemoci mikrobiologie přenos MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Research Support, N.I.H., Extramural MeSH
