Non-coding RNAs (ncRNAs) are important regulatory molecules involved in various physiological and pathological cellular processes. Small nucleolar RNAs (snoRNAs), subclass of small ncRNAs, have been considered important but unglamorous elements in the production of protein synthesis machinery of cells. However, recent evidence has indicated that these non-coding RNAs might have a crucial role also in controlling cell behavior, and snoRNAs dysfunction could significantly contribute to carcinogenesis. Here, we summarize the most important aspects of snoRNAs biology, their functioning in cancer cell, and potential usage in diagnosis or as a new class of therapeutic targets in cancer.

• MeSH
• alternativní sestřih MeSH
• cílená molekulární terapie MeSH
• fyziologický stres MeSH
• lidé MeSH
• malá jadérková RNA fyziologie   MeSH
• nádorové biomarkery fyziologie   MeSH
• nádory genetika   metabolismus   terapie   MeSH
• posttranskripční úpravy RNA MeSH
• regulace genové exprese u nádorů MeSH
• RNA interference MeSH
• sekvence nukleotidů MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH