• MeSH
• buněčné jádro * genetika   metabolismus   MeSH
• proteosyntéza * MeSH
• Publikační typ
• časopisecké články MeSH

The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects. In this review we integrate findings on the emerging mechanisms of activation, the signalling pathways and the spatio-temporal organization of the intra-S-phase DNA-damage checkpoint and its impact on the cell-cycle machinery, and discuss its biological significance.

• MeSH
• aktivace enzymů MeSH
• ATM protein MeSH
• buněčné linie MeSH
• časové faktory MeSH
• CDC geny MeSH
• checkpoint kinasa 2 MeSH
• DNA vazebné proteiny MeSH
• fosfatasy cdc25 metabolismus   MeSH
• lidé MeSH
• nádorové supresorové proteiny MeSH
• poškození DNA * MeSH
• protein-serin-threoninkinasy genetika   metabolismus   MeSH
• proteinkinasy metabolismus   MeSH
• proteiny buněčného cyklu * metabolismus   MeSH
• S fáze * fyziologie   MeSH
• signální transdukce fyziologie   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH

Checkpoint kinase 2 (Chk2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic evolution. Recent studies show the fundamental role of Chk2 in the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both hereditary and sporadic human cancers, and earmark this kinase as a candidate tumour suppressor and an attractive target for drug discovery.

• MeSH
• aktivace enzymů MeSH
• biologická evoluce MeSH
• biologické modely MeSH
• buněčný cyklus MeSH
• checkpoint kinasa 2 MeSH
• inhibitory enzymů farmakologie   MeSH
• lidé MeSH
• mutace MeSH
• nádory genetika   MeSH
• protein-serin-threoninkinasy * MeSH
• proteinkinasy fyziologie   genetika   chemie   MeSH
• racionální návrh léčiv MeSH
• signální transdukce MeSH
• tumor supresorové geny MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH