PURPOSE: The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. METHODS: The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. RESULTS AND CONCLUSIONS: The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.
Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) 12C-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper 12C-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + 11B → 3α reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses 10B-enriched BSH for neutron irradiation-triggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy's ballistic precision with the higher RBE promised by BNCT and 12C-ion therapy is thus demonstrated.
- MeSH
- alfa částice terapeutické užití MeSH
- bor chemie terapeutické užití MeSH
- borohydridy chemie MeSH
- buněčná smrt účinky záření MeSH
- chromozomální aberace účinky záření MeSH
- cyklotrony MeSH
- DNA nádorová genetika metabolismus účinky záření MeSH
- fluorescenční barviva chemie MeSH
- izotopy uhlíku chemie MeSH
- karyotypizace MeSH
- kombinovaná terapie přístrojové vybavení metody MeSH
- lidé MeSH
- lineární přenos energie MeSH
- nádorové buněčné linie MeSH
- nádory prostaty patologie radioterapie MeSH
- neutrony * MeSH
- poškození DNA MeSH
- protonová terapie * přístrojové vybavení metody MeSH
- relativní biologická účinnost MeSH
- sulfhydrylové sloučeniny chemie MeSH
- terapie metodou neutronového záchytu (bor-10) přístrojové vybavení metody MeSH
- vztah dávky záření a odpovědi MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
