The recent reports of the ill effects of amphetamine analogs are in stark contrast to the initial reports extolling their virtues that greeted the introduction of amphetamines to the World‘s pharmacopeia. This talk will present data from our controlled laboratory studies examining the acute and residual effects of amphetamine analogs in humans in an effort to better understand conditions under which positive and negative drugrelated effects are likely to occur. Special emphasis will be placed on physiological, cognitive, sleep and mood effects. Dr. Har t is an Associate Professor of Psychology in both the Departments of Psychiatry and Psychology at Columbia University, and Director of the Residential Studies and Methamphetamine Research Laborat ories at the New York Stat e Psychiatric Institute. A major focus of Dr. Hart‘s research is to understand behavioral, physiological, and subjective effects of psychoactive drugs in experienced users. He is the author or co-author of dozens of peerreviewed scientific articles in the area of substance abuse, co-author of the textbook, Drugs, Society, and Human Behavior, and a member of a National Institutes of Health (USA) review group. Dr. Hart was recently elected to Fellow status by the American Psychological Association (Division 28) for his outstanding contribution to the field of psychology specifically psychopharmacology and substance abuse.

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