New and modern techniques of drug design are extensively used in parallel or instead of the classic ones. Applicability of virtual screening (VS) is growing with the computational performance. This article includes list and short description of most frequent used methods in VS. These methods are divided into two groups – ligand-based VS and structure-based VS. Ligand based methods include chemical similarity, pharmacophore and quantitative structure-activity relationship. Molecular docking and scoring are methods of the structure-based VS.
- MeSH
- Models, Chemical MeSH
- Drug Discovery methods MeSH
- Computer Simulation MeSH
- Drug Design * MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
... Transmit Signals, and Are Linked into Macromolecules 9 -- Proteins Give Cells Structure and Perform Most ... ... | Protein Function 78 -- Specific Binding of Ligands Underlies the -- Functions of Most Proteins 78 - ... ... Genes and Noncoding DNA 223 -- Genomes of Many Organisms Contain Much -- Nonfunctional DNA 223 -- Most ... ... Eukaryotic Genes 282 -- Distant Enhancers Often Stimulate Transcription by RNA Polymerase II 284 -- Most ... ... of Intracellular Signal-Transduction Pathways 632 -- GTP-Binding Proteins Are Frequently Used As On/ ...
6th ed. xxxvii, 1150 s. : il., tab. ; 29 cm
- MeSH
- Cell Biology MeSH
- Molecular Biology MeSH
- Publication type
- Monograph MeSH
- Conspectus
- Biochemie. Molekulární biologie. Biofyzika
- NML Fields
- biologie
- cytologie, klinická cytologie
