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Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

Huggins, Ashley A
Author Huggins, Ashley A ORCID Brain Imaging and Analysis Center, Duke University, Durham, NC, USA. aahuggins@arizona.edu Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA. aahuggins@arizona.edu
Baird, C Lexi
Author Baird, C Lexi ORCID Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Briggs, Melvin
Author Briggs, Melvin Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Laskowitz, Sarah
Author Laskowitz, Sarah Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Hussain, Ahmed
Author Hussain, Ahmed ORCID Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Fouda, Samar
Author Fouda, Samar Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA Department of Psychiatry & Behavioral Sciences, Duke School of Medicine, Durham, NC, USA
Haswell, Courtney
Author Haswell, Courtney Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA
Sun, Delin
Author Sun, Delin Brain Imaging and Analysis Center, Duke University, Durham, NC, USA Department of Veteran Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center, Durham, NC, USA Department of Psychology, The Education University of Hong Kong, Ting Kok, Hong Kong
Salminen, Lauren E
Author Salminen, Lauren E Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA
Jahanshad, Neda
Author Jahanshad, Neda Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA

Molecular psychiatry. 2024 ; 29 (3) : 611-623. [pub] 20240110

Mol Psychiatry
ISSN 1476-5578
Medvik
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Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p-FDR < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD.

MeSH
White Matter pathology diagnostic imaging MeSH
Deep Learning MeSH
Adult MeSH
Middle Aged MeSH
Humans MeSH
Magnetic Resonance Imaging * methods MeSH
Cerebellum * pathology diagnostic imaging MeSH
Stress Disorders, Post-Traumatic * pathology physiopathology diagnostic imaging MeSH
Gray Matter pathology MeSH
Organ Size MeSH
Check Tag
Adult MeSH
Middle Aged MeSH
Humans MeSH
Male MeSH
Female MeSH
Publication type
Journal Article MeSH
Meta-Analysis MeSH

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