In this study, series of ring-substituted 2-styrylquinazolin-4(3H)-one and 4-chloro-2-styrylquinazoline derivatives were prepared. The syntheses of the discussed compounds are presented. The compounds were analyzed by RP-HPLC to determine lipophilicity. They were tested for their inhibitory activity on photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the synthesized compounds was also performed against four mycobacterial strains and against eight fungal strains. Several compounds showed biological activity comparable with or higher than that of the standard isoniazid. It was found that the electronic properties of the R substituent, and not the total lipophilicity of the compound, were decisive for the photosynthesis-inhibiting activity of tested compounds.

• MeSH
• antituberkulotika farmakologie   chemická syntéza   chemie   MeSH
• atypické mykobakteriální infekce farmakoterapie   MeSH
• bakteriální pneumonie farmakoterapie   mikrobiologie   MeSH
• chinazoliny farmakologie   chemická syntéza   chemie   MeSH
• chloroplasty účinky léků   MeSH
• fotosyntéza účinky léků   MeSH
• lidé MeSH
• netuberkulózní mykobakterie účinky léků   MeSH
• Spinacia oleracea účinky léků   MeSH
• styreny farmakologie   chemická syntéza   MeSH
• transport elektronů účinky léků   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• práce podpořená grantem MeSH