decode-and-forward
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Cognitive impairment is a dramatically increasing problem affecting many individuals as well as the health system. As we have no causal treatment for the loss of memory, symptomatic treatment is needed. Influencing the ACh system is a generally accepted approach, although other therapeutic treatments are in various stages of development. The multiple target drug approach using hybrid compounds may be another optimized move forward for the treatment of cognitive disorders. - Since the complex neuronal regulation is slowly being decoded, there is hope that ways will be found to stop neuronal loss and to generate new synapses.
- MeSH
- amyloidní beta-protein škodlivé účinky MeSH
- cholinesterasové inhibitory terapeutické užití MeSH
- farmakoterapie MeSH
- fixní kombinace léků MeSH
- kognitivní poruchy dějiny etiologie farmakoterapie MeSH
- lidé MeSH
- modely nemocí na zvířatech MeSH
- proteiny tau škodlivé účinky MeSH
- receptory histaminu H3 terapeutické užití MeSH
- receptory N-methyl-D-aspartátu antagonisté a inhibitory terapeutické užití MeSH
- Check Tag
- lidé MeSH
Over the course of history, human beings have never stopped seeking effective methods for information storage. From rocks to paper, and through the past several decades of using computer disks, USB sticks, and on to the thin silicon "chips" and "cloud" storage of today, it would seem that we have reached an era of efficiency for managing innumerable and ever-expanding data. Astonishingly, when tracing this technological path, one realizes that our ancient methods of informational storage far outlast paper (10,000 vs. 1,000 years, respectively), let alone the computer-based memory devices that only last, on average, 5 to 25 years. During this time of fast-paced information generation, it becomes increasingly difficult for current storage methods to retain such massive amounts of data, and to maintain appropriate speeds with which to retrieve it, especially when in demand by a large number of users. Others have proposed that DNA-based information storage provides a way forward for information retention as a result of its temporal stability. It is now evident that DNA represents a potentially economical and sustainable mechanism for storing information, as demonstrated by its decoding from a 700,000 year-old horse genome. The fact that the human genome is present in a cell, containing also the varied mitochondrial genome, indicates DNA's great potential for large data storage in a 'smaller' space.
... Variety of Subnuclear Aggregates 331 -- Summary 333 -- FROM RNA TO PROTEIN 333 -- An mRNA Sequence Is Decoded ... ... Acids Are Added to the C-terminal End of a Growing -- Polypeptide Chain 339 -- The RNA Message Is Decoded ... ... in Ribosomes 340 -- Elongation Factors Drive Translation Forward and Improve Its -- Accuracy 343 -- ... ... That Bind to the Same Gene -- Promoter Can Exert Combinatorial Control 520 -- An Incoherent Feed-forward ... ... Interaction Generates Pulses 522 -- A Coherent Feed-forward Interaction Detects Persistent Inputs 522 ...
Sixth edition xxxiv, 1430 stran v různém stránkování : ilustrace (převážně barevné) ; 29 cm
- Konspekt
- Biochemie. Molekulární biologie. Biofyzika
- NLK Obory
- molekulární biologie, molekulární medicína
- NLK Publikační typ
- učebnice vysokých škol
